Just drugs for Depression- Depression ppt Flashcards
Selective Serotonin Reuptake Inhibitors (SSRIs) examples
Fluoxetine (Prozac, Sarafem)
Sertraline (Zoloft)
Fluvoxamine (Luvox)
Paroxetine (Paxil, Pexeva)
Citalopram (Celexa)
Escitalopram (Lexapro, Cipralex)
Selective Serotonin Reuptake Inhibitors (SSRIs) side effects
feeling agitated, shaky or anxious
feeling or being sick
diarrhea or constipation
headache or dizziness
blurred vision
dry mouth
sexual dysfunction/ decreased libido
insomnia
sweating
Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs)
Desvenlafaxine (Pristiq)
Duloxetine (Cymbalta)
Levomilnacipran (Fetzima)
Venlafaxine (Effexor XR)
Serotonin/Norepinephrine Reuptake Inhibitors side effects
Common Side Effects
Nausea
Headache
Nervousness
Sweating
Insomnia*
Hypertension*
Sexual dysfunction*
Tricyclic Antidepressants
Amitriptyline (Elavil)
Nortriptyline (Pamelor)
Clomipramine (Anafranil)
Imipramine (Tofranil)
Doxepin (Silenor)
Tricyclic Antidepressants: management pearls
Administer at bedtime to reduce daytime sedation
Orthostatic hypotension: teach pts to sit or lie down when feeling lightheaded
Most dangerous adverse effect: Cardiac toxicity*
Tricyclic Antidepressants side effects sentence
Hot as a hare,
blind as a bat,
dry as a bone,
red as a beet,
mad as a hatter.
Monoamine Oxidase Inhibitors
Isocarboxazid (Marplan)
Phenelzine (Nardil)
Tranylcypromine (Parnate)
Selegiline (Emsam)
How often are MAOIs used?
rarely used due to side effect profile
Hypertensive crisis
-Severe headache, confusion
-Tachycardia, hypertension, profuse sweating
-Nausea and vomiting
-Stroke and death
To prevent hypertensive event while taking MAOIs:
avoid aged meat, bananas, smoked fish, cheese, wine, beer
Treatment for Hypertensive crisis caused by MAOIs
Treatment: Intravenous vasodilator
Labetalol, sodium nitroprusside, phentolamine
Atypical Antidepressants
Bupropion
When do effects of Bupropion begin?
Antidepressant effects begin in 1 to 3 weeks. A delayed antidepressant effect.
Bupropion can be given with what to increase effect?
Can be given with Paroxetine to augment effect.