introductory pharmacology

Question 1

pharmacodynamics

Answer 1

what a drug does to the body

Question 2

pharmacokinetics

Answer 2

what the body does to a drug

Question 3

receptors

Answer 3

protein macromolecules

Question 4

how are receptors divided ?

Answer 4

into 4 main super-families:
ligand gated ion channels
G-protein-coupled receptors
kinase linked receptors
nuclear receptors

Question 5

what is an agonist ?

Answer 5

drug that binds to a receptor to produce a cellular response

Question 6

what does an agonist posses ?

Answer 6

affinity
efficacy

Question 7

define affinity

Answer 7

strength of association between ligand and receptor

Question 8

define efficacy

Answer 8

ability of an agonist to evoke a cellular response

Question 9

what is an antagonist ?

Answer 9

drug that blocks the action of an agonist

Question 10

what does antagonist posses ?

Answer 10

affinity
lack efficacy

Question 11

what are two types of antagonists ?

Answer 11

competitive antagonist
non-competitive antagonism

Question 12

where dose a competitive antagonism bind ?

Answer 12

orthosteric site (same)

Question 13

what does competitive antagonism cause ?

Answer 13

parallel rightward shift of agonist concentration response curve with no depression in maximal response

Question 14

where does non-competitive antagonism occur ?

Answer 14

agonist - normal site
antagonists - allosteric site

Question 15

what does non-competitive antagonism cause ?

Answer 15

depress slop and maximum response curve, but do not cause a rightward shift