drug metabolism

Question 1

what are the two ways of metabolism ?

Answer 1

anabolism
catabolism

Question 2

anabolism

Answer 2

assimilation and complex structures from the building blocks of life

Question 3

what does anabolism require ?

Answer 3

energy

Question 4

catabolism

Answer 4

breakdown of molecules to obtain the anabolic “building blocks” of life and substrates for energy.

breakdown of molecules to yield energy

Question 5

what does metabolism do ?

Answer 5

convert drugs to more polar metabolites not readily absorbed in renal tubules, facilitating excretion

Question 6

what are the two phases of drug metabolism ?

Answer 6

phase 1 - RHS of liver
phase 2 - LHS of liver

Question 7

what occurs during phase one ?

Answer 7

oxidation, reduction and hydrolysis

makes a drug more polar

adds a chemically reactive group permitting conjugation

Question 8

what occurs in phase two ?

Answer 8

conjugation

adds an endogenous compound increasing polarity