Introduction to Haematology Flashcards
The physiological development process that gives rise to the cellular components of the blood.
Haemopoiesis
What are the 4 forms of self-renewal that a haematopoietic stem cell can undergo
Symetrical self-renewal
Asymetrical self renewal
Lack of self-renewal (2xP)
Lack of self-renewal
What type of self renewal increases the stem cell pool?
Symetrical self renewal
What type of self renewal maintains the stem cell pool and generates differentiated progeny?
Asymetrical self-renewal
What type of self-renewal depletes the stem cell pool and only generates differentiated progeny
Lack of self renewal
What are the 2 haematopoietic lineages
Myeloid
Lymphoid
At day 27, haemopoiesis starts where?
Aortagonad mesonephros region
At day 40, haematopoietic stem cells migrate where?
Foetal liver
Life span of erythrocytees
120 days
low RBCs
Anaemia
high RBCs
Polycythaemia
When plasma vol. is low and high conc of RBCs
Relative polycythaemia
What are the 2 major groups of leukocytes
Granulocytes (myeloid)
Lymphocytes (lymphoid)
Most common WBC
Neutrophils
Lifespan of neutrophils
A few hours
Increased numbers of neutrophils, when might this happen?
Neutrophilia e.g. infection, inflammation
Decreased numbers of neutrophils, when might this happen?
Neutropenia e.g. side effect of a drug
A rare WBC, part of the primative immune system
Basophils
Describe the differentiation of monocytes
Migrate to tissues and are then identified as macrophages. (histiocytes e.g. kupffer cells in liver, langerhans cells in skin)