Acute Leukaemia Flashcards
Accumulation of early myeloid or lymphoid precursors in the bone marrow, blood and other tissues
Acute leukaemia
Accumulation of early myeloid or lymphoid precursors in the bone marrow, blood and other tissues
Acute leukaemia
2 major groups of acute leukaemia
Acute lymphoblastic leukaemia
Acute myeloid leukaemia
Hamatopoietic blast cells constitute what proportion of the bone marrow?
> 20%
Clinical features of acute leukaemia
Features of bone marrow failure:
anaemia, infections, early bruising or haemorrhage, organ infiltration by leukaemic cells, ecchymoses
Give 2 examples of infections you might get in acute leukaemia
Staph A infection of orbit
Perianal infection with strep. faecalis, E.coli or oral candida
Why do you get ecchymoses in acute leukaemia
Thrombocytopenia
What is the difference between primary and secondary AML
Secondary AML follows previous myeloproliferative or myelodysplastic disease
What age group does AML affect?
All ages
Prognosis of AML
30-50% 15-55yrs
Type of acute leukaemia resulting from a chromosomal transolation in utero
ALL
Most common malignancy in childhood
AML
Prognosis of AML in childhood
80% cured
Lab features of acute leukaemia
Anaemia
Neutropenia
Thrombocytopenia
Lab features of acute leukaemia
Anaemia
Neutropenia
Thrombocytopenia