Acute Leukaemia

Question 1

Accumulation of early myeloid or lymphoid precursors in the bone marrow, blood and other tissues

Answer 1

Acute leukaemia

Question 2

Accumulation of early myeloid or lymphoid precursors in the bone marrow, blood and other tissues

Answer 2

Acute leukaemia

Question 3

2 major groups of acute leukaemia

Answer 3

Acute lymphoblastic leukaemia

Acute myeloid leukaemia

Question 4

Hamatopoietic blast cells constitute what proportion of the bone marrow?

Answer 4

> 20%

Question 5

Clinical features of acute leukaemia

Answer 5

Features of bone marrow failure:

anaemia, infections, early bruising or haemorrhage, organ infiltration by leukaemic cells, ecchymoses

Question 6

Give 2 examples of infections you might get in acute leukaemia

Answer 6

Staph A infection of orbit

Perianal infection with strep. faecalis, E.coli or oral candida

Question 7

Why do you get ecchymoses in acute leukaemia

Answer 7

Thrombocytopenia

Question 8

What is the difference between primary and secondary AML

Answer 8

Secondary AML follows previous myeloproliferative or myelodysplastic disease

Question 9

What age group does AML affect?

Answer 9

All ages

Question 10

Prognosis of AML

Answer 10

30-50% 15-55yrs

Question 11

Type of acute leukaemia resulting from a chromosomal transolation in utero

Answer 11

ALL

Question 12

Most common malignancy in childhood

Answer 12

AML

Question 13

Prognosis of AML in childhood

Answer 13

80% cured

Question 14

Lab features of acute leukaemia

Answer 14

Anaemia
Neutropenia
Thrombocytopenia

Question 15

Lab features of acute leukaemia

Answer 15

Anaemia
Neutropenia
Thrombocytopenia

Question 16

2 major groups of acute leukaemia

Answer 16

Acute lymphoblastic leukaemia

Acute myeloid leukaemia

Question 17

Hamatopoietic blast cells constitute what proportion of the bone marrow?

Answer 17

> 20%

Question 18

Clinical features of acute leukaemia

Answer 18

Features of bone marrow failure:

anaemia, infections, early bruising or haemorrhage, organ infiltration by leukaemic cells, ecchymoses

Question 19

Give 2 examples of infections you might get in acute leukaemia

Answer 19

Staph A infection of orbit

Perianal infection with strep. faecalis, E.coli or oral candida

Question 20

Why do you get ecchymoses in acute leukaemia

Answer 20

Thrombocytopenia

Question 21

What is the difference between primary and secondary AML

Answer 21

Secondary AML follows previous myeloproliferative or myelodysplastic disease

Question 22

What age group does AML affect?

Answer 22

All ages

Question 23

Prognosis of AML

Answer 23

30-50% 15-55yrs

Question 24

Type of acute leukaemia resulting from a chromosomal transolation in utero

Answer 24

ALL

Question 25

Most common malignancy in childhood

Answer 25

AML

Question 26

Prognosis of AML in childhood

Answer 26

80% cured

Question 27

4 major clinical features of acute leukaemia

Question 28

Lab features of acute leukaemia

Answer 28

Anaemia
Neutropenia
Thrombocytopenia

Question 29

Define neutropenic fever

Answer 29

Pyrexia in the presence of a neutrophil count

Question 30

Treatment of neutropenic fever

Answer 30

Broad spectrum IV antibiotics within 30 mins of temperature- tazocin or gentamicin