Cardiovascular Diseases 1 Flashcards
Inadequate blood supply to the myocardium
Ischaemic heart disease
What degree of coronary artery stenosis is insufficient at rest?
> 90%
At what stage in the heart cycle does most perfusion occur?
During diastole
3 types of angina pectoris
Stable/typical
Variant/prinzmetal
Crescendo/unstable
What type of angina is a fixed obstruction, predictable and related to exertion
Stable
What type of angina is due to a coronary artery spasm?
Varient/prinzmetal
What type of angina is often due to plaque disruption?
Crescendo/unstable
3 causes of acute coronary syndrome?
Acute MI with ST elevation
Acute MI without ST elevation
Unstable/crescendo angina
Give 2 types of MI, based on what area of the heart is affected
Subendocardial
Transmural
Is subendocardial MI associated with ST elevation?
No
Causes of subendocardial MI
Stable atheromatous occlusion
Acute hypotensive episode
What type of MI is caused by a sudden blockage that kills the whole wall?
Transmural
How do transmural MIs heal?
By scarring and fibrosis- no regeneration of myocytes and no contractile function
Causes of transmural MIs
Coronary atheroma and thrombus
Gross appearance of heart tissue
Normal/dark
Gross appearance of heart tissue 1-2 days after an MI
Yellow, infarct centre
Gross appearance of heart tissue 3-7 days after an MI
Hyperaemic border, yellow centre
Gross appearance of heart tissue
Red/grey
Gross appearance of heart tissue 3-6 weeks after an MI
Scar
Microscopic appearance of heart tissue
Necrosis and neutrophils
Microscopic appearance of heart tissue 1-2 days after an MI
More necrosis and neutrophils
Microscopic appearance of heart tissue 3-7 days after an MI
Macrophages
Microscopic appearance of heart tissue 1-3 weeks after an MI
Granulation tissue
Microscopic appearance of heart tissue 3-6 weeks after an MI
Collagen scar
At what point after an MI is the heart tissue the weakest?
3-7 days- infiltrated with macrophages