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Yr 3 > Intracellular Calcium Homeostasis > Flashcards

Intracellular Calcium Homeostasis Flashcards

1
Q

what does calmodulin do

A

facilitates smooth muscle contraction

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2
Q

where is Ca+ stored

A

endoplasmic reticulum

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3
Q

what is highly expressed in skeletal and cardiac muscle

A

calsequestrin

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4
Q

calsequestrin is highly expressed where

A

skeletal and cardiac muscle

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5
Q

name some pumps involevd in the entry point for calcium

A

Ca2+ATPases
Voltage gated Ca2+ channes
Na+/Ca2+ exchanger
permeability transition pore

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6
Q

when does Ca2+ ATPase transfer calcium

A

after the contraction of a muscle

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7
Q

what are the two kinds of Ca2+ ATPase

A

PMCA
SERCA

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8
Q

what is the ratio of ions moved in PMCA

A

H+1:1Ca2+

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9
Q

what is the ratio of ions moved in SERCA

A

H+2:2Ca2+

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10
Q

PMCA moves 1 Ca”+ out of each cell for each

A

H+ATP hydrolysed

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11
Q

How can PMCA activity be increases

A

binding of calmodulin to the C-terminal domain

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12
Q

SERCA moves 2 Ca2+ into ___________ for each ATP hydrolysed

A

sarcoplasmic reticulum

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13
Q

What are the 2 mian sites in SERCA and what is their corresponding affinitys

A

E1 - high calcium affinity
E2 - low calcium affinity

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14
Q

How can SERCA be regulated

A

ATP and phospholamban

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15
Q

Na+/Ca2+ is alos known as what

A

NCX

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16
Q

What family does NCX belong to

A

Ca2+/cation antiporter super family

17
Q

what is the ratio of ions moved in NCX

A

Na+3:1Ca2+

18
Q

in voltage gated calcium channels, how many subunits are there

A

4

19
Q

in voltage gated calcium channels, what are the subunits

A

alpha 1
B
alpha 2 delta
Gamma

20
Q

in voltage gated calcium channels, what is the largest subunit

A

alpha 1

21
Q

in voltage gated calcium channels, what subunit contains the ion selective residues (glutamine)

A

alpha 1

22
Q

in voltage gated calcium channels, what contains the voltage sensor

A

alpha 1

23
Q

in voltage gated calcium channels, where is the intracellular subunit

A

beta

24
Q

in voltage gated calcium channels, what subunit is the extracellular subunit

A

alpha2delta

25
Q

in voltage gated calcium channels, what subunit has two proteins joined by disulphide bridges

A

alpha2delta

26
Q

in voltage gated calcium channels, what subunit has variable effects on channel function

A

gamma

Yr 3 (15 decks)

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