Interstitial Kidney Disease Flashcards
What is interstitial nephritis?
Inflammation of the space between cells and tubules of the kidneys
What are the two types of interstitial nephritis?
Acute interstitial nephritis
Chronic tubulointerstitial nephritis.
What does acute interstitial nephritis account for?
25% of drug-induced acute kidney injury.
What is the acute inflammation of the tubules and interstitium due to?
Hypersensitivity reacvtion
How do patients with acute interstitial nephritis present?
fever, rash, arthralgia
eosinophilia
mild renal impairment
hypertension
What are the 3 main causes of acute interstitial nephritis?
drugs
systemic disease
infection
What are the possible drug causes of acute interstitial nephritis?
penicillin
rifampicin
NSAIDs
allopurinol
furosemide
What systemic disease could result in acute interstitial nephritis?
SLE
Sarcoidosis
Sjögren’s syndrome
What are the possible infective causes of acute interstitial nephritis?
Hanta virus
Staphylococci
What would you find on investigation of someone with acute interstitial nephritis?
Sterile pyuria
White cell casts
What is Chronic tubulointerstitial nephritis?
Chronic inflammation of the tubules and interstitium
How does chronic tubulointerstitial nephritis?
Chronic kidney disease.
Who is usually affected by chronic tubulointerstitial nephritis?
Young females
How can chronic tubulointerstitial nephritis present?
Fever
Weight loss
Painful, red eyes
