Integumentary Flashcards
What layer is deep to the dermis?
subcutaneous or hypodermis
lamellated corpuscles (pacinian)
nerve endings in hypodermis sensitive to pressure
What cells is the epidermis composed of?
keratinized stratified squamous epithelium; keratinocytes, melanocytes, intrepidermal macrophages, and tactile epithelial cells
What are lamellar granules and what produces them?
water-repellent sealant that decreases water entry and loss and inhibits the entry of foreign materials; keratinocytes
6 Functions of the skin
Regulate body temp, stores blood, protects, sensation, excretion/absorption, synthesis of vit D
Intraepidermal cells (Langerhans)
arise from red bone marrow, help other cells of the immune system recognize an invading microbe and destroy it
Tactile epithelial cells (Merkel)
located in the deepest layer of the epidermis, where they contact the flattened process of a sensory neuron, a structure called a tactile disc or Merkel disc
Strata of thin skin
stratum basale, stratum spinosum, stratum granulosum, and a thin stratum corneum
Where is thick skin located?
fingertips, palms, and soles
Strata of thick skin
stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and a thick stratum corneum
What is the stratum basale composed of?
single row of cuboidal or columnar keratinocytes; some stem cells (new kertatinocytes arise from)
What is the stratum spinosum composed of?
mainly consists of numerous keratinocytes arranged in 8–10 layers
What is the stratum granulosum composed of? Where is it in the epidermal layering?
Middle of epidermis; consists of 3 to 5 layers of flattened keratinocytes that are undergoing apoptosis, contain lamellar granules
What is keratohyalin and what layer are they found in?
granulosum; protein with darkly staining granules
What is the stratum lucidum composed of and where in the body is it located?
4 to 6 layers of flattened clear, dead keratinocytes that contain large amounts of keratin and thickened plasma membrane; only in thick skin
What is keratinization?
a processes of cells moving from one epidermal layer to the next and gaining more keratin as they go
What hormonelike protein regulates growth of skin?
epidermal growth factor
What is the dermis composed of?
dense irregular connective tissue containing collagen and elastic fibers
2 Layers of the dermis
papillary and reticular
Dominant cell found in dermis
fibroblasts
Papillary region
Superficial portion of dermis (about one-fifth); consists of areolar connective tissue with thin collagen and fine elastic fibers; contains dermal ridges that house blood capillaries, corpuscles of touch, and free nerve endings.
Dermal papillae
small, nipple-shaped structures that project into
the undersurface of the epidermis; increase surface area of papillary region; contain capillary loop, corpuscles of touch, and free nerve endings
Reticular region
Deeper portion of dermis (about four-fifths); consists of dense irregular connective tissue with bundles of thick collagen and some coarse elastic fibers. Spaces between fibers contain some adipose cells, hair follicles, nerves, sebaceous glands, and sudoriferous glands.
Epidermal ridges
downward projections of the epidermis into the dermis between the dermal papillae of the papillary region