Inflammation

Question 1

Characteristics of chronic inflammation:
      increased number of macrophages
      lasts for several weeks
      connective tissue growth
      lymphocyte infiltration

Answer 1

increased number of macrophages
lasts for several weeks
connective tissue growth
lymphocyte infiltration

Question 2

Characteristics of acute inflammation:
 duration of maximum 1 week
      macrophage infiltration
      connective tissue growth
      lymphocytic infiltration

Answer 2

duration of maximum 1 week

Question 3

It is true about leukocyte adhesion deficiency type 1 (LAD1):
it is a defect of CD11/ CD18 integrins
it is a defect of the selectin receptors
a problem of the membrane component of NADPH oxidases
a problem of the cytoplasmic component of NADPH oxidases
a lack of the MPO-H2O2 system

Answer 3

it is a defect of CD11/ CD18 integrins

Question 4

Phases of inflammation:
      proliferation
      vascular reaction
      reparation
      stasis

Answer 4

proliferation
vascular reaction
reparation

Question 5

Chemotactic agent of endogenous origin:
      C5a, C3a
      LTB4
      IL-8
      LPS

Answer 5

C5a, C3a
LTB4
IL-8

Question 6

Shows decreased activity in patients with diabetes mellitus:
  chemotaxis
  adhesion
  phagocytosis
  wound healing

Answer 6

chemotaxis
adhesion
phagocytosis
wound healing

Question 7

Negative acute phase proteins:
      albumin
      transferrin
      ceruloplasmin
      α1 -protease inhibitor

Answer 7

albumin

transferrin

Question 8

Positive acute phase proteins:
      albumin
      transferrin
      ceruloplasmin
      α1 -protease inhibitor

Answer 8

ceruloplasmin

Question 9

Effects of plasmin:
FDP production and vasodilation as a result
it removes the fibrin mesh
activates the complement system by cleaving C3
increases venula permeability

Answer 9

FDP production and vasodilation as a result
it removes the fibrin mesh
activates the complement system by cleaving C3

Question 10

Plasminogen activator
 bacterial compounds (eg streptokinase)
 cellular compounds (eg trypsin)
 macrophag plasminogen-activator
 Hageman-factor

Answer 10

bacterial compounds (eg streptokinase)

Hageman-factor

Question 11

Chemical mediators increasing vascular permeability:
                 vasoactive amines
                C3a and C5a
                  bradykinin
                  PGI2, TXA2

Answer 11

vasoactive amines
C3a and C5a
bradykinin

Question 12

Characteristic for chronic inflammation:
 accumulation of lymphocytes and macrophages
 angiogenesis
 vasodilation
 edema formation

Answer 12

accumulation of lymphocytes and macrophages

angiogenesis

Question 13

Which deficiency causes recurrent pyogenic infections?
 deficient antibody production
 deficient complement function
 deficient phagocyte function
 deficient killer T lymphocyte function

Answer 13

deficient complement function

deficient phagocyte function

Question 14

Effects of bradykinin
 arteriola dilatation
 increases in venula permeability
 plasminogen activation
 C1q activation

Answer 14

arteriola dilatation

increases in venula permeability

Question 15

Hageman factor (factor XII) activators
 collagen
 plasmin
 lipopolisaccharid (LPS)
 C3a

Answer 15

collagen

Question 16

Mediators increasing the inflammatory reaction:
      IL-1
      IL-2
      IL-6
      IL-10

Answer 16

IL-1

IL-6

Question 17

Mediators playing a role in fever formation
 IL-1
 TNFα
 LPS
 PGI2

Answer 17

IL-1
TNFα
LPS

Question 18

Participate in the inflammatory process
 eosinophil granulocyte
 platelet
 mast cell
 endothel

Answer 18

eosinophil granulocyte
platelet
mast cell
endothel

Question 19

Effective therapies against hereditary angioedema (HAE)
  C1-esterase-inhibitor
 intravenous  corticosteroid
 antihistamin
 intravenous adrenalin
 Na-chromoglycat

Answer 19

C1-esterase-inhibitor

Question 20

TRUE OR FALSE

The selectins play an important role in the initiation of the “rolling” process.

Answer 20

True

Question 21

TRUE OR FALSE

The selectins play an important role in extravasation.

Answer 21

False

Question 22

TRUE OR FALSE

Integrins play an important role in extravasation

Answer 22

True

Question 23

TRUE OR FALSE

P-selectins are stored in platelets and are liberated in response to the inflammatory reaction.

Answer 23

False

Question 24

TRUE OR FALSE

Plasmin causes vasidilation throught FDPs (fibrin degradation products)

Answer 24

True

Question 25

TRUE OR FALSE Plasmin enhances the removal of deposited fibrin.

Answer 25

True

Question 26

TRUE OR FALSE Plasmin activates the complement system through C3 cleavage.

Answer 26

True

Question 27

TRUE OR FALSE Plasmin activates the complement system through C1 cleavage

Answer 27

False