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Pathophysiology 1 MCQ > Inflammation > Flashcards

Inflammation Flashcards

1
Q 
Characteristics of chronic inflammation:
      increased number of macrophages
      lasts for several weeks
      connective tissue growth
      lymphocyte infiltration
A

increased number of macrophages
lasts for several weeks
connective tissue growth
lymphocyte infiltration

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2
Q 
Characteristics of acute inflammation:
 duration of maximum 1 week
      macrophage infiltration
      connective tissue growth
      lymphocytic infiltration
A

duration of maximum 1 week

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3
Q

It is true about leukocyte adhesion deficiency type 1 (LAD1):
it is a defect of CD11/ CD18 integrins
it is a defect of the selectin receptors
a problem of the membrane component of NADPH oxidases
a problem of the cytoplasmic component of NADPH oxidases
a lack of the MPO-H2O2 system

A

it is a defect of CD11/ CD18 integrins

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4
Q 
Phases of inflammation:
      proliferation
      vascular reaction
      reparation
      stasis
A

proliferation
vascular reaction
reparation

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5
Q 
Chemotactic agent of endogenous origin:
      C5a, C3a
      LTB4
      IL-8
      LPS
A

C5a, C3a
LTB4
IL-8

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6
Q 
Shows decreased activity in patients with diabetes mellitus:
  chemotaxis
  adhesion
  phagocytosis
  wound healing
A

chemotaxis
adhesion
phagocytosis
wound healing

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7
Q 
Negative acute phase proteins:
      albumin
      transferrin
      ceruloplasmin
      α1 -protease inhibitor
A

albumin

transferrin

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8
Q 
Positive acute phase proteins:
      albumin
      transferrin
      ceruloplasmin
      α1 -protease inhibitor
A

ceruloplasmin

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9
Q

Effects of plasmin:
FDP production and vasodilation as a result
it removes the fibrin mesh
activates the complement system by cleaving C3
increases venula permeability

A

FDP production and vasodilation as a result
it removes the fibrin mesh
activates the complement system by cleaving C3

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10
Q 
Plasminogen activator
 bacterial compounds (eg streptokinase)
 cellular compounds (eg trypsin)
 macrophag plasminogen-activator
 Hageman-factor
A

bacterial compounds (eg streptokinase)

Hageman-factor

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11
Q 
Chemical mediators increasing vascular permeability:
                 vasoactive amines
                C3a and C5a
                  bradykinin
                  PGI2, TXA2
A

vasoactive amines
C3a and C5a
bradykinin

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12
Q 
Characteristic for chronic inflammation:
 accumulation of lymphocytes and macrophages
 angiogenesis
 vasodilation
 edema formation
A

accumulation of lymphocytes and macrophages

angiogenesis

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13
Q 
Which deficiency causes recurrent pyogenic infections?
 deficient antibody production
 deficient complement function
 deficient phagocyte function
 deficient killer T lymphocyte function
A

deficient complement function

deficient phagocyte function

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14
Q 
Effects of bradykinin
 arteriola dilatation
 increases in venula permeability
 plasminogen activation
 C1q activation
A

arteriola dilatation

increases in venula permeability

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15
Q 
Hageman factor (factor XII) activators
 collagen
 plasmin
 lipopolisaccharid (LPS)
 C3a
A

collagen

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16
Q 
Mediators increasing the inflammatory reaction:
      IL-1
      IL-2
      IL-6
      IL-10
A

IL-1

IL-6

17
Q 
Mediators playing a role in fever formation
 IL-1
 TNFα
 LPS
 PGI2
A

IL-1
TNFα
LPS

18
Q 
Participate in the inflammatory process
 eosinophil granulocyte
 platelet
 mast cell
 endothel
A

eosinophil granulocyte
platelet
mast cell
endothel

19
Q 
Effective therapies against hereditary angioedema (HAE)
  C1-esterase-inhibitor
 intravenous  corticosteroid
 antihistamin
 intravenous adrenalin
 Na-chromoglycat
A

C1-esterase-inhibitor

20
Q

TRUE OR FALSE

The selectins play an important role in the initiation of the “rolling” process.

A

True

21
Q

TRUE OR FALSE

The selectins play an important role in extravasation.

A

False

22
Q

TRUE OR FALSE

Integrins play an important role in extravasation

A

True

23
Q

TRUE OR FALSE

P-selectins are stored in platelets and are liberated in response to the inflammatory reaction.

A

False

24
Q

TRUE OR FALSE

Plasmin causes vasidilation throught FDPs (fibrin degradation products)

A

True

25
Q

TRUE OR FALSE

Plasmin enhances the removal of deposited fibrin.

A

True

26
Q

TRUE OR FALSE

Plasmin activates the complement system through C3 cleavage.

A

True

27
Q

TRUE OR FALSE

Plasmin activates the complement system through C1 cleavage

A

False

Pathophysiology 1 MCQ (16 decks)

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