Hypertension Flashcards
Factors influencing mean arterial pressure (MAP): cardiac output total peripheral resistance heart rate contractility
cardiac output
total peripheral resistance
heart rate
contractility
Main effects of angiotensin II through AT1-receptors:
increases kidney blood flow
decreases of aldosterone secretion
enhances renin production
vasoconstriction resulting in blood pressure increases
vasoconstriction resulting in blood pressure increases
Aldosterone function, effects:
regulation of extracellular volume
transformation of angiotensinogen produced by the liver to angiotensin I which will change to angiotensin II in the lungs
regulation of potassium balance
increases liquid intake by affecting thirst center in the hypothalamus
increases liquid intake by affecting thirst center in the hypothalamus
As a result of prolonged hypertension, which alterations affect the vessel wall:
increasing shear stress at blood flow
increasing vessel wall elasticity
increasing endothelial damage
decreasing vessel wall permeability
increasing shear stress at blood flow
increasing endothelial damage
Factors/causes influencing essential hypertension: high NaCl-intake kidney disease excessive alcohol consumption psychosocial stress
high NaCl-intake
kidney disease
excessive alcohol consumption
psychosocial stress
Hypertension may cause the following: chest pain fatigue positional vertigo, blurred vision dizziness
chest pain
fatigue
positional vertigo, blurred vision
dizziness
Hypertension is defined by the following parameters:
systolic value ≥ 130 mmHg, diastolic value ≥ 80 mmHg
systolic value ≥ 135 mmHg, diastolic value ≥ 85 mmHg
systolic value ≥ 140 mmHg, diastolic value ≥ 90 mmHg
systolic value ≥ 145 mmHg, diastolic value ≥ 95 mmHg
systolic value ≥ 140 mmHg, diastolic value ≥ 90 mmHg
Which statements are false?
The conversion of renin to angiotensin I is catalyzed by the ACE
ACE inhibitors are anithypertensive drugs
angiotensin II is a strong vasopressor: it induces arterial contraction and increases the blood pressure
angiotensin I is the only known substrate of renin
The conversion of renin to angiotensin I is catalyzed by the ACE
angiotensin I is the only known substrate of renin
What is isolated systolic lhypertension?
systolic ≤120 mmHg, diastolic ≤70 mmHg
systolic ≤130 mmHg, diastolic ≤80 mmHg
systolic ≤125 mmHg, diastolic ≤75 mmHgm
systolic ≥ 140 mmHg, diastolic <90 mmHg
systolic ≥ 140 mmHg, diastolic <90 mmHg
What are the complications of hypertension? Chronic renal failure Heart failure Stroke Peripheral vascular disease
Chronic renal failure
Heart failure
Stroke
Peripheral vascular disease
Possible causes of secondary hypertension: primary hyperaldosteronism Cushing’s syndrome sleep apnea increased salt intake
primary hyperaldosteronism
Cushing’s syndrome
increased salt intake
Which factors affect the blood pressure? sympathetic nervous system activity heart rate renal function serum ALP activity
sympathetic nervous system activity
heart rate
renal function
Which statements are true about bradykinine?
It promotes the production of NO and prostaglandin in endothelial cells
It relaxes the blood vessels
It increases the blood pressure
It is a vasoconstrictor
It promotes the production of NO and prostaglandin in endothelial cells
It relaxes the blood vessels
Which statements are true about growth factors?
they promote the thickening of vessel walls
They increases the diameter of blood vessels
They increase the body height
They increase the blood flow
they promote the thickening of vessel walls
They increase the body height
Which factors promote the proliferation of smooth muscle cells? Endothelin Epidermal growth factor (EGF) Protacyclin NO
Endothelin
Epidermal growth factor (EGF)
Which factors inhibit the proliferation of smooth muscle cells? Prostacyclin Kinins ( bradykinin and kallidin) Fibroblast growth factor (FGF) Angiotensin II
Prostacyclin
Kinins ( bradykinin and kallidin)
Which statements are true about renovascular hypertension?
In the patomechanism of renovascular hypertension, the renin-angiotensin-aldosteron-system (RAAS) plays a decisive role
In renovascular hypertension, plasma renin activity can be normal or elevated in response to reduced renal blood flow
Renin reduces the blood pressure
Secondary hyperaldosteronism decreases the sodium reabsorption in the kidney
In the patomechanism of renovascular hypertension, the renin-angiotensin-aldosteron-system (RAAS) plays a decisive role
In renovascular hype
(? In renovascular hypertension, plasma renin activity can be normal or elevated in response to reduced renal blood flow ?)
What are the complications of hypertension? Retinopathy and blindness Stroke Heart failure Polycystic renal disease
Retinopathy and blindness
Stroke
Heart failure
Atrial natriuretic peptide (ANP) may have the following effects:
urinary sodium loss
diuretic effect
antiproliferative effect
urinary sodium loss with fluid retention
urinary sodium loss
diuretic effect
Which statements are true about the treatment of hypertension?
A combination of lifestyle changes and drug treatment may be necessary
A healthy diet is recommended: low salt and fat content but rich in dietary fiber
Treating the secondary causes of hypertension is necessary
The therapeutic target value is 150/90 mmHg
A combination of lifestyle changes and drug treatment may be necessary
A healthy diet is recommended: low salt and fat content but rich in dietary fiber
Treating the secondary causes of hypertension is necessary
Which factors play role in the pathogenesis of hypertension: genetic factors high salt intake smoking physical inactivity
genetic factors
high salt intake
smoking
physical inactivity
Hypertension may lead to the following complications: retinal hemorrhage glomerulopathy left ventricular hypertrophy cataract
retinal hemorrhage
glomerulopathy
left ventricular hypertrophy
cataract
What are the potential central nervous system disorders in hypertension? Hemorrhagic stroke Ruptured brain aneurysm Parkinson's disease Huntington's disease
Hemorrhagic stroke
Ruptured brain aneurysm
What is the mechanism of hyperaldosteronism induced hypertension?
increased sodium retention thereby increasing a intravascular volume
decreased potassium secretion in the kidney
increased plasma potassium levels
increased intracellular calcium levels in smooth muscle cells
increased sodium retention thereby increasing a intravascular volume
increased intracellular calcium levels in smooth muscle cells