Diabetes Flashcards

1
Q

Which statements are true about Diabetes?
It is a risk factor for cardiovascular disease
It is the main cause of endstage renal disease
It is the main cause of blindness in adults
It is a major cause of non-traumatic limb amputation

A

It is a risk factor for cardiovascular disease
(? It is the main cause of endstage renal disease ?)
It is the main cause of blindness in adults
It is a major cause of non-traumatic limb amputation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which are the actions of Insulin?
It increases triglyceride synthesis in the adipose tissue
It increases the glycogen synthesis in muuscle
It inhibits the production of ketone bodies in the liver
It increases the glucose uptake in beta cells in the pancreas

A

It increases triglyceride synthesis in the adipose tissue

It increases the glycogen synthesis in muuscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is C peptide?
A cleavage product of proinsulin
A synonym of C-reactive protein
A synonym of the anticoagulant Protein C
It is synonymous to anti-insulin antibody

A

A cleavage product of proinsulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which statements are true about Idiopathic type I diabetes?
It is a rare disease
No evidence of autoimmunity is present
Severe insulin deficinecy may be present, but insulin requirement widely varies
The etiology is well known

A

It is a rare disease
No evidence of autoimmunity is present
Severe insulin deficinecy may be present, but insulin requirement widely varies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which are the acute complications of diabetes?
diabetic ketoacidic coma
diabetic hyperosmolar (non-ketotic) coma
Lactic acidosis
renal failure

A
diabetic ketoacidic coma
 diabetic hyperosmolar (non-ketotic) coma
 Lactic acidosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q
What kind of autoantibodies are commonly found in type 1 diabetes?
 islet cell autoantibodies
 glutamic acid decarboxylase autoantibodies
 insulin autoantibodies (IAAs)
 insulin receptor autoantibodies are the most common autoantibodies
A
islet cell autoantibodies
 glutamic acid decarboxylase autoantibodies
 insulin autoantibodies (IAAs)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which statements are true about type 1 Diabetes?
Insulin is needed for survival
It starts with a sudden onset
It accounts for 20% of diabetes
Insulin resistance is the chief characteristic of type 1 diabetes

A

Insulin is needed for survival

It starts with a sudden onset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which statements are true about type 1 diabetes?
Patients are prone to ketosis
The disease mostly occurs in children or in the youth
Since insulin is administered, no dietary changes are necessary
Genetic determination of susceptibility plays a key role in the pathogenesis of the disease

A

Patients are prone to ketosis
The disease mostly occurs in children or in the youth

Genetic determination of susceptibility plays a key role in the pathogenesis of the disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What does “honeymoon phase “ mean in type 1 diabetes?
A phase of low insulin requirement following the start of insulin treatment, when the preserved beta cells still produce insulin
A phase when the patient does not require insulin treatment
A stage when the autoantibodies disappear
A phase when the patient has no symptoms

A

A phase of low insulin requirement following the start of insulin treatment, when the preserved beta cells still produce insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which statements are true about type 2 diabetes
Insulin level may be low, normal or elevated
Many patients are overweight or obese
It often cause ketoacidosis
There is strong correlation between type 2 diabetes and specific HLA haplotypes

A

Insulin level may be low, normal or elevated

Many patients are overweight or obese

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which statements are true about type 2 diabetes?
Insulin resistance is a characteristic feature of the disease
Genetic predisposition is stronger for type 2 than in type 1 diabetes
Late complication may be detectable at the time of diagnosis
It never occurs in children

A

Insulin resistance is a characteristic feature of the disease
Genetic predisposition is stronger for type 2 than in type 1 diabetes
Late complication may be detectable at the time of diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which statements are true about gestational diabetes?
Blood glucose levels usually normalize after the birth of the baby
The prevalence of gestational diabetes is 2-4%
It is a risk factor for type 2 diabetes
Recurrrence rate during a subsequent pregnancy is 1%

A

Blood glucose levels usually normalize after the birth of the baby
The prevalence of gestational diabetes is 2-4% (LECTURE: 5-9%, but it is close, so I don’t know)
It is a risk factor for type 2 diabetes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which statements are true about glycemic index?
It is important to know the glycemic index of foods in diabetes
High glycemic index foods increase the blood sugar faster than low glycemic foods
High glycemic foods increase the blood sugar for a longer period
Only the glycemic index is important in the diet of diabetic patients and not the absolute amount of carbohydrates

A

It is important to know the glycemic index of foods in diabetes
High glycemic index foods increase the blood sugar faster than low glycemic foods

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which statements are true about GLUT 4 translocation in skeletal muscle cells?
Insulin binding to insulin receptor strimulates the translocation of GLUT4 transportersis responsible for (RESPONSIBLE FOR WHAT?)
Physical exercise promotes GLUT4 translocation in an insulin-independent fashion
Physical exercise promotes GLUT4 translocation via an insulin-dependent mechanism
Physical exercise does not affect the translocation of GLUT4 transporters

A

Physical exercise promotes GLUT4 translocation via an insulin-dependent mechanism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q
Hypoglycemia may cause the following:
Tachycardia
 Confusion
 Muscle cramps
 Dry, warm skin
A

Tachycardia
Confusion
Muscle cramps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the role of IRS (insulin receptor substrate) in the development of insulin resistance:
TNF-alpha induces IRS-1 phosphorylation at serine residues that cause insulin resistance
Excessive amount of fatty acids induce serine phosphorylation of IRS1 and cause insulin resistance
If IRS1 is phosphorylated at any site it will cause insulin resistance
IRS1 plays a key role in insulin signalling but it is not involved in the pathogenesis of insulin resistance

A

TNF-alpha induces IRS-1 phosphorylation at serine residues that cause insulin resistance

17
Q
What are the chronic complications of diabetes?
 Retinopathy
 Nephropathy
 Ischemic heart disease
 Idiopathic myelofibrosis
A

Retinopathy
Nephropathy
Ischemic heart disease

18
Q
What statements are true about LADA?
 Autoantibodies are detectable in LADA
 It begins over the age of 30-35 years
 Oral antidiabetics may be sufficient in the beginning of the disease
 It is synonymous to MODY
A

Autoantibodies are detectable in LADA
It begins over the age of 30-35 years
Oral antidiabetics may be sufficient in the beginning of the disease

19
Q
Which genetic syndromes are sometimes associated with diabetes?
Turner syndrome
 Down syndrome
 Klinefelter syndrome
 Duchenne syndrome
A

Turner syndrome
Down syndrome
Klinefelter syndrome

20
Q
Which gene's polymorphism affect the susceptibility to type 1 diabetes?
 MDA5
 OAS1
 IFIH1
 PMN2
A

MDA5
OAS1
IFIH1

21
Q
Which ones are the microvascular complications of diabetes?
 Retinopathy
 Nephropahty
 Neuropahty
 Coronary sclerosis
A

Retinopathy
Nephropahty
Neuropahty

22
Q

Which statements are true about LADA?
Its clinical presentation resembles type 2 diabetes
LADA patients will require insulin treatment during their lifetime
It occurs only in Asian people
Autoantibodies are never detectable

A

LADA patients will require insulin treatment during their lifetime

23
Q
Which of the following may be a symptom of diabetes?
 Recurring candida infections in infants
 Pruritus vulvae
 unconsciousness
 ketosis
A

Recurring candida infections in infants
Pruritus vulvae
unconsciousness
ketosis

24
Q

What are the consensus criteria of ketoacidosis in children?
Blood sugar > 11.0 mmol/l
pH < 7.3 or plasma bicarbonate <15 mmol/l
ketosis or ketonuria
Detectable GAD antibody

A

Blood sugar > 11.0 mmol/l
pH < 7.3 or plasma bicarbonate <15 mmol/l
ketosis or ketonuria

25
Q

Which statements are true about type 2 diabetes?
Ketoacidosis mostly occurs in patients who have other diseases
Its prevalence increases in younger patients
It increases the risk of cardiovascular diseases
Mumps and Coxsackievirus infections play a significant role in the development of type 2 diabets

A

Its prevalence increases in younger patients

It increases the risk of cardiovascular diseases

26
Q

Which statements are true about MODY?
Mutations in the glucokinase gene are the most common cause of MODY?
It accounts for a low percentage of diabetes
It is a synonym of juvenile onset diabetes
It is a subtype of type 1 diabetes

A

Mutations in the glucokinase gene are the most common cause of MODY?
It accounts for a low percentage of diabetes
It is a synonym of juvenile onset diabetes

27
Q

Which statements are true about hyperosmolar nonketotic coma?
It mostly occurs in type 2 diabetes patients
Blood sugar levels may reach 80-100 mmol/l values
Its mortality is high
Severe acidosis develops due to lactic acid production (but not because of oveproduction of ketone bodies)

A

It mostly occurs in type 2 diabetes patients
Blood sugar levels may reach 80-100 mmol/l values
Its mortality is high