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SEROLOGY > Infectious Mononucleosis (EBV) > Flashcards

Infectious Mononucleosis (EBV) Flashcards

1
Q

Self-limiting disease caused by EPSTEIN-BARR VIRUS

A

Infectious Mononucleosis

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2
Q

confused with:

Diphtheria
Pharyngitis
Vincent’s Angina
Lymphadenitis
Scarlet Fever
Hepatitis
Pertussis

A

Infectious Mononucleosis

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3
Q

Classis symptoms of Infectious Mononucleosis:

A

Fever
Lymphadenopathy
Sore throat

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4
Q

MOT of Epstein-Barr Virus

A

Saliva
Blood Transfusion
Transplacental

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5
Q

EBV infects

A

B cells

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6
Q

Lymphocyte produce in response to the EBV infection has same characteristics with

A

T cell

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7
Q

EBV infection acquired from blood transfusion is known as

A

IM Postperfusion Syndrome

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8
Q

Other associated conditions in EBV

A

Burkitt’s Lymphoma
Nasopharyngeal Carcinoma

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9
Q

Initial infection of EBV usually manifest in

A

Oropharynx

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10
Q

EBV can integrate into DNA genome and transform to

A

malignant cells

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11
Q

Enlarged Lymphocytes with atypical nuclei

A

Downey cells

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12
Q

Antibodies that cross-react in the group of similar antigens found in unrelated animals and microorganisms

A

Heterophile antibodies

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13
Q

Usually appears in the acute phase of IM

A

IgM

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14
Q

Heterophile antibodies cross reacts with

A

Horse
Ox
Sheep’s RBC

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15
Q

Heterophile antibody are absorbed by

A

Beef erythrocytes

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16
Q

Heterophile antibody are NOT absorbed by

A

Guinea pig kidney cells

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17
Q

DOES NOT react with EBV-specific antigen

A

Heterophile antibody

18
Q

Serological Test for IM:

Principle: Hemagglutination
Screening Test only

Px serum + Sheep’s RBC

A

Paul-Bunnel Screening Test

19
Q

In Paul-Bunnel Screening Test; Heterophile Antibody titer is reported as the

A

Reciprocal of the HIGHEST DILUTION showing agglutination

20
Q

Normal titer in Paul-Bunnel Screening Test

A

< 56

21
Q

Differentiate Heterophile Antibodies found in IM, Serum Sickness, Forssman Antigen

A

Davidsohn Differential Test

22
Q

Davidsohn Differential Test observe absorption with (2)

A

Guinea Pig Kidney Cells
Beef RBC’s

23
Q

Davidsohn Differential Test observe agglutination with

A

Sheep’s RBC

24
Q

Absorbed by Guinea Pig Kidney Cells and Beef RBC

A

Serum sickness

25
Q

Absorbed by Guinea Pig cell and NOT ABSORBED BY BEEF RBC

A

Forssman antigen

26
Q

NOT ABSORBED BY Guinea Pig Cell but ABSORBED BY BEEF RBC

A

Infectious Mononucleosis

27
Q

Do not observed Guinea Pig Kidney cells

A

IM

28
Q

Do not observed Beef RBC

A

Forssman antigen

29
Q

Guinea Pig Kidney (-) ; Agglutinate with Sheep’s rbc

A

Infectious mononucleosis

30
Q

Beef’s RBC (-) ; Agglutinate with Sheep’s RBC

A

Forssman antigen

31
Q

Also a differential Test but requires absorption of Patient’s serum

A

Monospot Test/Rapid Differential Slide Test

32
Q

In Monospot Test/ Rapid Differential Slide Test it is uses to agglutinate with Heterophile antibodies

A

Horse RBC

33
Q

detectable in the early course of Infection

A

IgM Anti-VCA

34
Q

Detectable AFTER SHOWING SIGNS AND SYMPTOMS

May persist for Life

A

IgG Anti-VCA

35
Q

Strongly indicates ACTIVE INFECTION
Reactivation of Latent Infection
Not consistent indicator of EBV

A

IgG Anti-EA-D

36
Q

Found in the serum of very young children but NOT IN YOUNG ADULTS

A

IgG Anti-EA-R

37
Q

found in the nucleus of ALL EBV-infected cells

Does not stimulate antibody until after incubation of IM

A

EBNA

38
Q

appears during convalescence

A

Anti-EBNA

39
Q

EBNA stands for

A

Epstein Barr Nuclear Antigen

40
Q

VCA stands for

A

Viral Capsid Antigen

41
Q

Have a higher level of specificity and are considered GOLD STANDARD OF EBV SEROLOGIC METHOD

A

Indirect Immunofluorescence assays (IFA)

SEROLOGY (17 decks)

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