I: Syphilis

Question 1

Syphilis was brought from ____ to ____

Answer 1

NOSy

New world to Old world

Question 2

Syphilis is previously called as

Answer 2

Great pox
Evil pox

Question 3

MOT of Syphilis

Answer 3

Sexual
Blood Transfusion
Transplacental

Question 4

Causative Agent of Syphilis

Answer 4

Treponema pallidum

Question 5

First diagnostic test for syphilis

Answer 5

Wasserman Test (1906)

Question 6

Wasserman Test uses ___ Ag

Answer 6

Cardiolipin

Question 7

First Treatment used for syphilis

Answer 7

Salvarsan (606) : Arsephenamine

Question 8

Drug of Choice for Syphilis

Answer 8

Penicillin G

Question 9

Early or Untreated early latent syphilis marker

Answer 9

IgM

Question 10

Early immune response, becomes predominant marker for Syphilis

Answer 10

IgG

Question 11

Greatest elevation of IgG is observed at what stage of syphilis

Answer 11

2nd Stage of Syphilis

Question 12

Nonspecific antibodies against protein antigen group that are common to PATHOGENIC SPIRPCHETES

Answer 12

Nontreponemal Antibodies

Question 13

Nontreponemal Antibodies are also called as

Answer 13

Reagin

Question 14

Reagin are produced by infected individuals to act against on

Answer 14

Acts against on their own cell or Mammalian Cells

Question 15

Nontreponemal Antibodies are also seen in patient with other infectious diseases such as

Answer 15

Measles
Chicken pox
Hepatitis
Leprosy
Tuberculosis
IM
Leptospirosis
Malaria
Ricketsial disease
Trypanosomiasis
Lymphogranuloma venereum

Question 16

Reagin is also seen in patient with Noninfectious condition such as

Answer 16

Autoimmune disorder
Old Age
Pregnancy
Drug Addiction
Recent Immunization

Question 17

STAGE OF SYPHILIS:

Hard Chancre but painless

Answer 17

Primary stage

Question 18

STAGE OF SYPHILIS:

Condylomata Lata
Generalized rashes

Answer 18

Secondary Stage

Question 19

STAGE OF SYPHILIS:

No signs and symptoms
(+) serologic test

Answer 19

Late Latent Stage

Question 20

STAGE OF SYPHILIS:

Neurosyphilis
Gummas
Cardiovascular conditions

Answer 20

Tertiary stage

Question 21

localized areas of granulomatous inflammation

Answer 21

Gummas

Question 22

CV conditions is charactized with

Answer 22

Aortic aneurysm
Aortic regurgitation
Angina pectoris

Question 23

can span to all stages of Syphilis

Answer 23

Neurosyphilis

Question 24

Irreversible type of Neurosyphilis

Answer 24

Parenchymatous neurosyphilis

Question 25

Parenchymatous syphilis is characterized with

Answer 25

Paresis Tabes Dorsalis

Question 26

degeneration of dorsal spinal cord and sensory nerve trunks

Answer 26

Tabes dorsalis

Question 27

- incomplete paralysis

Answer 27

paresis

Question 28

LABORATORY TEST: Direct Detection of Syphilis can be done through (2)

Answer 28

Dark Field Microscopy Fluorescent Antibody Test

Question 29

LABORATORY TEST: It is observed under Dark Field Microscopy

Answer 29

Corkscrew Motility of T. pallidum

Question 30

LABORATORY TEST: False (-) Result in Dark Field Microscopy is due to

Answer 30

1. Delayed in evaluating the slide 2. Insufficient specimen 3. Pretreatment of Antibiotics

Question 31

LABORATORY TEST: Highly sensitive and Specific Do not require the use of Live organism Can be used Indirectly/Direct

Answer 31

Fluorescent Antibody

Question 32

Serologic Test for Syphilis can be done through (2)

Answer 32

Nontreponemal Test Treponemal Test

Question 33

What is being detected in Nontreponemal Test

Answer 33

Reagin (Antilipoidal, Anticardiolipin, Non treponamal Ab)

Question 34

Lipid material secreted from damaged cells

Answer 34

Cardiolipin

Question 35

Reagin acts on the lipid antigen secreted from animal (beef heart)

Answer 35

Flocculation

Question 36

Serologic Test for Syphilis Nonspecific Used for Screening only

Answer 36

Nontreponemal Test

Question 37

Nontreponemal Test gives False (+) result in conditions with

Answer 37

SLE RA IM

Question 38

Serologic Test for Syphilis Detects Antibodies for T. pallidum

Answer 38

Treponemal Test

Question 39

Specimen of choice for evaluation of LATENT SYPHILIS OR TERTIARY SYPHILIS

Answer 39

CSF

Question 40

Precipitation that occurs over a NARROW RANGE OF ANTIGEN CONCENTRATION Antigen consist of VERY FINE PARTICLES that clump together

Answer 40

Flocculation

Question 41

Syphilis can mimic those of many other disease, thus called

Answer 41

The great imitator