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SEROLOGY > I: Syphilis > Flashcards

I: Syphilis Flashcards

1
Q

Syphilis was brought from ____ to ____

A

NOSy

New world to Old world

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2
Q

Syphilis is previously called as

A

Great pox
Evil pox

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3
Q

MOT of Syphilis

A

Sexual
Blood Transfusion
Transplacental

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4
Q

Causative Agent of Syphilis

A

Treponema pallidum

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5
Q

First diagnostic test for syphilis

A

Wasserman Test (1906)

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6
Q

Wasserman Test uses ___ Ag

A

Cardiolipin

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7
Q

First Treatment used for syphilis

A

Salvarsan (606) : Arsephenamine

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8
Q

Drug of Choice for Syphilis

A

Penicillin G

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9
Q

Early or Untreated early latent syphilis marker

A

IgM

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10
Q

Early immune response, becomes predominant marker for Syphilis

A

IgG

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11
Q

Greatest elevation of IgG is observed at what stage of syphilis

A

2nd Stage of Syphilis

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12
Q

Nonspecific antibodies against protein antigen group that are common to PATHOGENIC SPIRPCHETES

A

Nontreponemal Antibodies

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13
Q

Nontreponemal Antibodies are also called as

A

Reagin

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14
Q

Reagin are produced by infected individuals to act against on

A

Acts against on their own cell or Mammalian Cells

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15
Q

Nontreponemal Antibodies are also seen in patient with other infectious diseases such as

A

Measles
Chicken pox
Hepatitis
Leprosy
Tuberculosis
IM
Leptospirosis
Malaria
Ricketsial disease
Trypanosomiasis
Lymphogranuloma venereum

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16
Q

Reagin is also seen in patient with Noninfectious condition such as

A

Autoimmune disorder
Old Age
Pregnancy
Drug Addiction
Recent Immunization

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17
Q

STAGE OF SYPHILIS:

Hard Chancre but painless

A

Primary stage

18
Q

STAGE OF SYPHILIS:

Condylomata Lata
Generalized rashes

A

Secondary Stage

19
Q

STAGE OF SYPHILIS:

No signs and symptoms
(+) serologic test

A

Late Latent Stage

20
Q

STAGE OF SYPHILIS:

Neurosyphilis
Gummas
Cardiovascular conditions

A

Tertiary stage

21
Q

localized areas of granulomatous inflammation

A

Gummas

22
Q

CV conditions is charactized with

A

Aortic aneurysm
Aortic regurgitation
Angina pectoris

23
Q

can span to all stages of Syphilis

A

Neurosyphilis

24
Q

Irreversible type of Neurosyphilis

A

Parenchymatous neurosyphilis

25
Q

Parenchymatous syphilis is characterized with

A

Paresis
Tabes Dorsalis

26
Q

degeneration of dorsal spinal cord and sensory nerve trunks

A

Tabes dorsalis

27
Q
  • incomplete paralysis
A

paresis

28
Q

LABORATORY TEST:

Direct Detection of Syphilis can be done through (2)

A

Dark Field Microscopy
Fluorescent Antibody Test

29
Q

LABORATORY TEST:

It is observed under Dark Field Microscopy

A

Corkscrew Motility of T. pallidum

30
Q

LABORATORY TEST:

False (-) Result in Dark Field Microscopy is due to

A
  1. Delayed in evaluating the slide
  2. Insufficient specimen
  3. Pretreatment of Antibiotics
31
Q

LABORATORY TEST:

Highly sensitive and Specific
Do not require the use of Live organism
Can be used Indirectly/Direct

A

Fluorescent Antibody

32
Q

Serologic Test for Syphilis can be done through (2)

A

Nontreponemal Test
Treponemal Test

33
Q

What is being detected in Nontreponemal Test

A

Reagin (Antilipoidal, Anticardiolipin, Non treponamal Ab)

34
Q

Lipid material secreted from damaged cells

A

Cardiolipin

35
Q

Reagin acts on the lipid antigen secreted from animal (beef heart)

A

Flocculation

36
Q

Serologic Test for Syphilis

Nonspecific
Used for Screening only

A

Nontreponemal Test

37
Q

Nontreponemal Test gives False (+) result in conditions with

A

SLE
RA
IM

38
Q

Serologic Test for Syphilis

Detects Antibodies for T. pallidum

A

Treponemal Test

39
Q

Specimen of choice for evaluation of LATENT SYPHILIS OR TERTIARY SYPHILIS

A

CSF

40
Q

Precipitation that occurs over a NARROW RANGE OF ANTIGEN CONCENTRATION

Antigen consist of VERY FINE PARTICLES that clump together

A

Flocculation

41
Q

Syphilis can mimic those of many other disease, thus called

A

The great imitator

SEROLOGY (17 decks)

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