I: Syphilis Flashcards
Syphilis was brought from ____ to ____
NOSy
New world to Old world
Syphilis is previously called as
Great pox
Evil pox
MOT of Syphilis
Sexual
Blood Transfusion
Transplacental
Causative Agent of Syphilis
Treponema pallidum
First diagnostic test for syphilis
Wasserman Test (1906)
Wasserman Test uses ___ Ag
Cardiolipin
First Treatment used for syphilis
Salvarsan (606) : Arsephenamine
Drug of Choice for Syphilis
Penicillin G
Early or Untreated early latent syphilis marker
IgM
Early immune response, becomes predominant marker for Syphilis
IgG
Greatest elevation of IgG is observed at what stage of syphilis
2nd Stage of Syphilis
Nonspecific antibodies against protein antigen group that are common to PATHOGENIC SPIRPCHETES
Nontreponemal Antibodies
Nontreponemal Antibodies are also called as
Reagin
Reagin are produced by infected individuals to act against on
Acts against on their own cell or Mammalian Cells
Nontreponemal Antibodies are also seen in patient with other infectious diseases such as
Measles
Chicken pox
Hepatitis
Leprosy
Tuberculosis
IM
Leptospirosis
Malaria
Ricketsial disease
Trypanosomiasis
Lymphogranuloma venereum
Reagin is also seen in patient with Noninfectious condition such as
Autoimmune disorder
Old Age
Pregnancy
Drug Addiction
Recent Immunization
STAGE OF SYPHILIS:
Hard Chancre but painless
Primary stage
STAGE OF SYPHILIS:
Condylomata Lata
Generalized rashes
Secondary Stage
STAGE OF SYPHILIS:
No signs and symptoms
(+) serologic test
Late Latent Stage
STAGE OF SYPHILIS:
Neurosyphilis
Gummas
Cardiovascular conditions
Tertiary stage
localized areas of granulomatous inflammation
Gummas
CV conditions is charactized with
Aortic aneurysm
Aortic regurgitation
Angina pectoris
can span to all stages of Syphilis
Neurosyphilis
Irreversible type of Neurosyphilis
Parenchymatous neurosyphilis
Parenchymatous syphilis is characterized with
Paresis
Tabes Dorsalis
degeneration of dorsal spinal cord and sensory nerve trunks
Tabes dorsalis
- incomplete paralysis
paresis
LABORATORY TEST:
Direct Detection of Syphilis can be done through (2)
Dark Field Microscopy
Fluorescent Antibody Test
LABORATORY TEST:
It is observed under Dark Field Microscopy
Corkscrew Motility of T. pallidum
LABORATORY TEST:
False (-) Result in Dark Field Microscopy is due to
- Delayed in evaluating the slide
- Insufficient specimen
- Pretreatment of Antibiotics
LABORATORY TEST:
Highly sensitive and Specific
Do not require the use of Live organism
Can be used Indirectly/Direct
Fluorescent Antibody
Serologic Test for Syphilis can be done through (2)
Nontreponemal Test
Treponemal Test
What is being detected in Nontreponemal Test
Reagin (Antilipoidal, Anticardiolipin, Non treponamal Ab)
Lipid material secreted from damaged cells
Cardiolipin
Reagin acts on the lipid antigen secreted from animal (beef heart)
Flocculation
Serologic Test for Syphilis
Nonspecific
Used for Screening only
Nontreponemal Test
Nontreponemal Test gives False (+) result in conditions with
SLE
RA
IM
Serologic Test for Syphilis
Detects Antibodies for T. pallidum
Treponemal Test
Specimen of choice for evaluation of LATENT SYPHILIS OR TERTIARY SYPHILIS
CSF
Precipitation that occurs over a NARROW RANGE OF ANTIGEN CONCENTRATION
Antigen consist of VERY FINE PARTICLES that clump together
Flocculation
Syphilis can mimic those of many other disease, thus called
The great imitator
