II: Human Immunodeficiency Virus (HIV)

Question 1

GAG:

Inner surface of envelope

Answer 1

p17

Question 2

GAG:

Core coat of nucleic acids

Answer 2

p24

Question 3

GAG:

Core binding protein

Answer 3

p9

Question 4

GAG:

Binds with genomic RNA

Answer 4

p7

Question 5

ENVELOPE (env):

Binds with CD4 T cells

Answer 5

gp120

Question 6

ENVELOPE (env):

transmembrane protein

Answer 6

gp41

Question 7

POLYMERASE (Pol)

subunit of reverse transcriptase

Answer 7

p66
p51

Question 8

POLYMERASE (Pol)

degrades RNA genome to DNA

Answer 8

p66

Question 9

POLYMERASE (Pol)

Integrase
Mediates integration of viral DNA to host genome

Answer 9

p31

Question 10

POLYMERASE (Pol)

Protease that cleaves gag precursor

Answer 10

p10

“proTENease”

Question 11

activates transcription of HIV provirus

Answer 11

tat (p14)

Question 12

transfer of mRNA to cytoplasm of host cell

Answer 12

rev (p19)

Question 13

enhances HIV replication

Answer 13

nef (p27)

Question 14

Viral assembly and budding

Answer 14

vpu (p16)

Question 15

Integration of HIV DNA into host genome

Answer 15

vpr (p15)

Question 16

Infectivity factor

Answer 16

vif (p23)

Question 17

precursor protein which forms core proteins

Answer 17

p55

Question 18

core proteins are

Answer 18

p6
p7
p17
p24

Question 19

p66
p51
p31
p10
Rnase

Answer 19

Polymerase (Pol)

Question 20

gp160
gp120
gp41

Answer 20

env (envelope)

Question 21

Current CDC classification system for HIV identification and AIDs categorizes patients based on

Answer 21

• Clinical conditions
• CD4 T-cell count

Question 22

best indicator of the immediate state of immunologic competence of patient with HIV infection

Answer 22

CD4 T cell count

Question 23

HIV disease is classified as ____ if one or more specific opportunistic illness has been diagnosed

Answer 23

Stage 3

Question 24

Slim’s disease is also known as

Answer 24

AIDS

• severe weight loss

Question 25

Example of AIDS-defining Illnesses

Answer 25

Esophageal candidiasis
Invasive Cervical Cancer
CMV Retinitis
HIV encephalopathy
Kaposi Sarcoma
Burkitt’s Lymphoma
P. jirovecii pneumonia

Question 26

MAIN DIFFICULTY ASSOCIATED WITH THE DEVELOPMENT OF HIV VACCINE

Answer 26

Different strains are genetically diverse