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SEROLOGY > II: Human Immunodeficiency Virus (HIV) > Flashcards

II: Human Immunodeficiency Virus (HIV) Flashcards

1
Q

GAG:

Inner surface of envelope

A

p17

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2
Q

GAG:

Core coat of nucleic acids

A

p24

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3
Q

GAG:

Core binding protein

A

p9

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4
Q

GAG:

Binds with genomic RNA

A

p7

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5
Q

ENVELOPE (env):

Binds with CD4 T cells

A

gp120

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6
Q

ENVELOPE (env):

transmembrane protein

A

gp41

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7
Q

POLYMERASE (Pol)

subunit of reverse transcriptase

A

p66
p51

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8
Q

POLYMERASE (Pol)

degrades RNA genome to DNA

A

p66

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9
Q

POLYMERASE (Pol)

Integrase
Mediates integration of viral DNA to host genome

A

p31

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10
Q

POLYMERASE (Pol)

Protease that cleaves gag precursor

A

p10

“proTENease”

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11
Q

activates transcription of HIV provirus

A

tat (p14)

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12
Q

transfer of mRNA to cytoplasm of host cell

A

rev (p19)

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13
Q

enhances HIV replication

A

nef (p27)

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14
Q

Viral assembly and budding

A

vpu (p16)

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15
Q

Integration of HIV DNA into host genome

A

vpr (p15)

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16
Q

Infectivity factor

17
Q

precursor protein which forms core proteins

18
Q

core proteins are

A

p6
p7
p17
p24

19
Q

p66
p51
p31
p10
Rnase

A

Polymerase (Pol)

20
Q

gp160
gp120
gp41

A

env (envelope)

21
Q

Current CDC classification system for HIV identification and AIDs categorizes patients based on

A
  • Clinical conditions
  • CD4 T-cell count
22
Q

best indicator of the immediate state of immunologic competence of patient with HIV infection

A

CD4 T cell count

23
Q

HIV disease is classified as ____ if one or more specific opportunistic illness has been diagnosed

24
Q

Slim’s disease is also known as

A

AIDS

  • severe weight loss
25
Q

Example of AIDS-defining Illnesses

A

Esophageal candidiasis
Invasive Cervical Cancer
CMV Retinitis
HIV encephalopathy
Kaposi Sarcoma
Burkitt’s Lymphoma
P. jirovecii pneumonia

26
Q

MAIN DIFFICULTY ASSOCIATED WITH THE DEVELOPMENT OF HIV VACCINE

A

Different strains are genetically diverse

SEROLOGY (17 decks)

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