Hepatitis Flashcards
Acquired from: Picornaviridae
MOT: Fecal Oral
Incubation: 28 days
Chronicity: No
Hepatitis A
Usually seen in the feces of patient with Hepa A during INCUBATION and EARLY ACUTE INFECTION
HAV Antigen
Primary Marker for Hepatitis A infection
IgM anti-HAV
Hepatitis A: Marker for immunity; persist for life
IgG anti-HAV
Detection of Hepatitis A in clinical, food, and water
HAV RNA
Family: Hepadnaviridae
MOT: Parenteral, Sexual, Perinatal
Incubation: 30-180 days
Chronicity: Yes
Hepatitis B
Hepatitis B marker for:
- Active Infection
- First Marker to appear
- Important Marker for Screening Blood donors
HBsAg (surface)
Hepatitis B marker for:
- High degree of INFECTIVITY & high vertical transmission risk
- Active Replication
HBeAg (envelope)
Hepatitis B marker for:
- cannot be detected in serum due to the envelope that masks it
- retrieved by Biopsy only in the liver
HBcAg (core)
Hepatitis B Marker:
- Current or Recent Infection
- Useful in detecting Window period
IgM Anti-Hbc
Hepatitis B Marker:
- life-long marker
IgG Anti-Hbc
Hepatitis B Marker:
- Recovery from infection
- Convalescence marker (good prognosis)
Anti-Hbe
Hepatitis B Marker:
Immunity to hepatitis B (Protective titer: > 10 mIU/mL)
Anti-Hbs
Acute, Atypical, or occult Hepatitis B
HBV DNA
Hepatitis B marker:
Used to monitor for effectiveness of therapy
Viral Load Test
Highly correlated with the presence of whole virus replication and potential infectivity of patient
HBV DNA
Hepatitis C is acquired from the family of
Flaviviridae
Family: Hepadnaviridae
MOT: Parenteral, Sexual, Perinatal
Incubation: 7-8 weeks
Chronicity: Yes
Hepatitis C
(Non-A Non-B Hepatitis)
Hepatitis C Marker:
Current or past infection
Anti-HCV
Hepatitis C Marker:
Viral Load Test to monitor effectiveness of therapy
HCV RNA
aka Post Transfusion Hepatitis
Hepatitis C
Surrogate test for HCV
Increase ALT
(+) Anti-Hbc
Specific Test for HCV
(+) Anti-HCV
Treatment for Hepatitis C and Kaposi Sarcoma
IFN alpha
Acquired from the family of DELTA viruses (RNA)
Hepatitis D
Family: Delta virus
MOT: Mostly Parenteral but can be transmitted Sexual, Perinatal
Chronicity: Yes
Hepatitis D
Hepatitis D:
Coninfection
SiMultaneously
IgM
Hepatitis D:
Superinfection
Seqqqqquentialy
IgG
Hepatitis E is acquired from the family of
Hepeviridae
Caliciviridae
Family: Hepevirus / Calicivirus
MOT: Fecal Oral
Incubation: 2-6 weeks
Chronicity: No
Hepatitis E
Hepatitis E Marker:
Current Infection
IgM anti-HEV
Hepatitis E Marker:
Current/Past Infection
IgG anti-HEV
Hepatitis E Marker:
HEV RNA
Current infection
associated with fulminant liver failure in pregnant woman
Hepatitis E
ORDER OF APPEARANCE OF HEPA B MARKERS
S E C E S
Antigen Antibody
SE CES
May be transmitted by clotting factor components
Hepatitis A
Infectious Hepatitis
Dane particle is found in hepatitis
Hepatitis B
Serum Hepatitis
