Group A Streptoccocal Infection Flashcards

1
Q

Onset of symptoms of Rheumatic fever or glomerulonephritis is associated with

A

Antibody response

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2
Q

During acute and convalascent phase of infection (group A infection) there should be

A

4 fold increase of Ab titer

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3
Q

Based on the neutralization hemolysin of Streptolysin O

A

Antistreptolysin O Titer

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4
Q

Antistreptolysin O Titer:

Titer is reported as:

A

Reciprocal of Highest Dilution showing NO HEMOLYSIS

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5
Q

Antistreptolysin O Titer:

Is expressed as

A

Todd Units
International Units

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6
Q

Antistreptolysin O Titer:

Normal Titer

A

< 166 Todd units

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7
Q

Antistreptolysin O Titer:

Moderately elevated (Adult)

A

> 240 Todd units

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8
Q

Antistreptolysin O Titer:

Moderately elevated (child)

A

> 320 Todd Units

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9
Q

Based on the Neutralization of depolymerizing activity of DNAse b

A

Anti DNAse B Test

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10
Q

Anti DNAse B Test

If there is no antibody present, the test will show

A

colorless

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11
Q

Anti DNAse B Test

Anti DNAse B is present, the test will show

A

green color remains

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12
Q

Stain used for Anti DNAse Test

A

Methyl green

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13
Q

Anti DNAse B test are graded:

4+

A

Intensity unchanged

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14
Q

Anti DNAse B Test

0

A

Loss of color

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15
Q

Slide agglutination screening test

A

Streptozyme Test

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16
Q

detection of antibodies to several streptococcal antigen

A

Streptozyme Test

17
Q

In streptozyme test, what is being coated in antigens

A

Sheep’s RBC

18
Q

Streptozyme Test:

Antigens used for coating the SHEEP’s RBC

A

Streptokinase
Streptolysin
Hyaluronidase
DNAse
NADase

19
Q

Streptozyme Test:

Positive Reaction

A

Hemagglutination

20
Q

Gold standard for detection of Rickettsial infection

A

Indirect Fluorescence Assay (IFA)
Microimmunofluorescence (micro-IF)

21
Q

gram-positive cocci
Lancet shaped
appears in chains and pairs
Alpha, Gamma, Beta hemolysis

A

Streptococci

22
Q

Primary reservoir of Group A streptococcus

A

Humans

23
Q

Group A strep primarily affects

A

Upper Respiratory Tract
Skin

24
Q

Group A strep common clinical manifestation

A

Pharyngitis
Streptococcal pyoderma

25
Q

2 sequelae of Group A strep Infection

A

Acute Rheumatic Fever
Poststreptococcal glomerulonephritis