Infectious Diseases - Antivirals

Question 1

What is maraviroc and what is it used for?

Answer 1

It is a CCR5 inhibitor used in HIV

Question 2

What are the classes of HAART in HIV and examples?

Answer 2

1. NRTI (nucleoside reverse transcriptase inhibitor)
   - lamivudine
   - TDF - gives fanconis - high phosphaturia, glycosuria, uricidaemia, - prodrug - short half life, kidney takes up free tenofovir - kidney damage via mitochondrial toxicity
   - TAF
   - emtricitabine
   - Abacavir

2 NNRTI (does not find at the deoxybucleotide binding site)
- nevirapine
- efavirenze

3. Protease inhibitors
   - ritonavir - used to boost other PIs
   - lopinavir
4. Integrate inhibitors
   - dolutegravir
   - raltegravir