Haematology - Cytogenetics

Question 1

Pair the cytogenetic abnormalities in NHL for:
1. Burkitt’s lymphoma
2. Follicular lymphoma
3. Mantle cell lymphoma
4, peripheral T cell lymphoma
5. Anaplastic large cell lymphoma

Answer 1

1. t(8:15)
2. t(14;18)
3. t(11;14)
4. t(5;9)
5. t(2;5)

Question 2

Apml translocation

Answer 2

T(15:17)

Question 3

Philadelphia chromosome and where can you find it

Answer 3

T(9;22), found in CML and ALL. Use imatinib if present. Poor prognosis in ALL