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Pharma > Immunsupressiva > Flashcards

Immunsupressiva Flashcards

0
Q

Mycophenolat-mofetil

A

Purinsynthese geht runter –>
Zellproliferation geht runter.

Indikation:
Transplantation

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1
Q

Methotrexat

A

Purin- und
Thymidinsynthese geht runter –>
Zellproliferation geht runter

Indikation:
Rheumatoide Arthritis

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2
Q

Azathioprin

A

Purinsynthese geht runter, Antimetabolit,Einbau als falscher Basenbaustein
—>
Zellproliferation geht runter.

Indikation:
Transplantation
Autoimmunerkrankung

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3
Q

Ciclosporin

Tacrolimus

A

Calcineurin-Inhibition –> aktiviert normal ->NF-AT(Nuclear-Factor-Activating-T-cells)
IL-2 Synthese geht runter
Zellproliferation geht runter.

Indikation:
Transplantation
Autoimmunerkrankung

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4
Q

Sirolimus

Everolimus

A

mTOR-Inhibition –> reguliert normalerweise Zellzyklus und Zellproliferation –>
Zellproliferation geht runter

Indikation:
Transplantation

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5
Q

Muromonab

A

CD3 T-Zellrezeptor –> ist wichtig für Pofileration–>
T-Zell Apoptose

Indikation:
akute Transplantat-abstoßung

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6
Q

Basiliximab

Daclizumab

A

IL-2 Rezeptorblockade –>
Zellproliferation geht runter

Indikation:
Transplantation

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