Immunology Review Flashcards
AE of cisplatin
Nephrotoxicity and acoustic nerve damage
AE of bleomycin/ busulfan
Pulmonary fibrosis
AE of vincristine
Peripheral neuropathy
AE of doxorubicin
Cardiotoxicity
AE of cyclophosphamide
hemorrhagic cystitis
AE of trastuzumab
CHF
Mechanism of trastuzumab
monocolnal antibody against HER-2
Disease that rituximab is used for
B cell neoplasms (NHL)
Mech of rituximab
antibody against CD-20
Mechanism of bevacizumab
Ab against VEGF
inhibits angiogenesis
Mechanism of Omalizumab
Anti-IGE
When is Omalizumab used
severe asthma
Mechanism of Infliximab
Anti-TNF alpha
When is inflixumab used
Chron’s, RA
When is abciximab used
some acute coronary syndromes
Mechanism of abciximab
Anti-glycoprotein IIB/IIIA
Type I Hypersensitivity
preformed antibody IgE mediated immediate symptoms: -allergy -atopy -anaphylaxis
Type II Hypersensitivity
cytotoxic reactions of antibody against cells or tissues:
Hemolytic anemia
Goodpastures
Type III Hypersensitivity
antigen-antibody complex deposition in tissue: Vasculitis serum sickness post-strep GN Arthus reaction
What is an Arthrus reaction
edema and skin necrosis caused by activation on complement
Type IV Hypersensitivity
T cell mediated Delayed presentation: - TB skin test -contact dermatitis -Graft v Host disease
Antibody found in scleroderma
Anti-ScL-70, anti-topoisomerase 1
Antibody in drug induced lupus
Anti-histone
Antibody in Autoimmune hepatitis
Anti-smooth muscle
Antibody in primary biliary cirrhosis
Anti-mitochondrial
Antibody in Celiac’s
Anti-tissue transglutaminase
Mechanism of hereditary angioedema
decreased C1 esterase inhibitor
Infant boy (4-6 months)
encapsulated organism sepsis
absent B cells
X-linked (Bruton’s) agammaglobulinemia
Young adult recurrent sinusitis, pneumonia, bonchiectasis splenomegaly malignancies GI malacpsorbption
Common variable immunodeficiency (B and T cell deficiency)
CHD (truncus arteriosis)
hypoparathyroid
facial abnormalities
low T cells
congenital thymic aplasia
DiGerorge
Recurrent Nisseria infections
Terminal complement deficiency (C5-C9)
Boy
chronic catalase + infections
+ nitroblue tetrazolium
Chronic Granulomatous Disease
Eczema, thrombocytopenia
x linked
combined B and T cell deficiency
Wiskott Aldrich
Agammaglobulinemia
lymphopenia
infant
SCID
By either adenosine deaminase deficiency or defective IL2 receptors
Infant recurrent bacterial infections persistent neutrophilia absent pus delayed separation of the umbilical cord
Leukocyte adhesion deficiency
Mechanism by which steroids cause low WBC?
glucocorticoid induced demargination and storage poor release of neutrophils
What drugs can induce neutropenia?
Sulfa drugs
PTU
Which antibodies are produced in delayed transfusion reactions?
anti-Kell and Duffy
Post transfusion uticaria puritis wheezing fever
Allergic reaction
Type 1 hypersensitivity against plasma proteins in transfused blood
Post transfusion Dyspnea bronchospasm hypotension resspiratory arrest
Anaphylactic reaction
IgA deficient patients after receiving blood
Post transfusion
fever, chilld within 12 hours
no hemolysis
Febrile non hemolytic transfusion reaction
Type II- host antibodies against donor antigens and WBCs
Post transfusion immediate fever hypotension flank pain brown urine immediate
Acute hemolytic transfusion reaction
ABO mismatch
Post transfusion (1-2 weeks)
jaundice
slow hmeolysis
Delayed hemolytic transfusion reaction
Shortness of air during transfusion
lung crackles
Volume overload
Post transfusion fever dyspnea noncardiogenic pulmonary edema esp after FFP
transfusion associated acute lung injury (TRALI)
