Immunology Review

Question 1

AE of cisplatin

Answer 1

Nephrotoxicity and acoustic nerve damage

Question 2

AE of bleomycin/ busulfan

Answer 2

Pulmonary fibrosis

Question 3

AE of vincristine

Answer 3

Peripheral neuropathy

Question 4

AE of doxorubicin

Answer 4

Cardiotoxicity

Question 5

AE of cyclophosphamide

Answer 5

hemorrhagic cystitis

Question 6

AE of trastuzumab

Answer 6

CHF

Question 7

Mechanism of trastuzumab

Answer 7

monocolnal antibody against HER-2

Question 8

Disease that rituximab is used for

Answer 8

B cell neoplasms (NHL)

Question 9

Mech of rituximab

Answer 9

antibody against CD-20

Question 10

Mechanism of bevacizumab

Answer 10

Ab against VEGF

inhibits angiogenesis

Question 11

Mechanism of Omalizumab

Answer 11

Anti-IGE

Question 12

When is Omalizumab used

Answer 12

severe asthma

Question 13

Mechanism of Infliximab

Answer 13

Anti-TNF alpha

Question 14

When is inflixumab used

Answer 14

Chron’s, RA

Question 15

When is abciximab used

Answer 15

some acute coronary syndromes

Question 16

Mechanism of abciximab

Answer 16

Anti-glycoprotein IIB/IIIA

Question 17

Type I Hypersensitivity

Answer 17

preformed antibody
IgE mediated
immediate symptoms:
-allergy
-atopy
-anaphylaxis

Question 18

Type II Hypersensitivity

Answer 18

cytotoxic reactions of antibody against cells or tissues:
Hemolytic anemia
Goodpastures

Question 19

Type III Hypersensitivity

Answer 19

antigen-antibody complex deposition in tissue:
Vasculitis
serum sickness
post-strep GN
Arthus reaction

Question 20

What is an Arthrus reaction

Answer 20

edema and skin necrosis caused by activation on complement

Question 21

Type IV Hypersensitivity

Answer 21

T cell mediated
Delayed presentation:
- TB skin test
-contact dermatitis
-Graft v Host disease

Question 22

Antibody found in scleroderma

Answer 22

Anti-ScL-70, anti-topoisomerase 1

Question 23

Antibody in drug induced lupus

Answer 23

Anti-histone

Question 24

Antibody in Autoimmune hepatitis

Answer 24

Anti-smooth muscle

Question 25

Antibody in primary biliary cirrhosis

Answer 25

Anti-mitochondrial

Question 26

Antibody in Celiac's

Answer 26

Anti-tissue transglutaminase

Question 27

Mechanism of hereditary angioedema

Answer 27

decreased C1 esterase inhibitor

Question 28

Infant boy (4-6 months) encapsulated organism sepsis absent B cells

Answer 28

X-linked (Bruton's) agammaglobulinemia

Question 29

``` Young adult recurrent sinusitis, pneumonia, bonchiectasis splenomegaly malignancies GI malacpsorbption ```

Answer 29

Common variable immunodeficiency (B and T cell deficiency)

Question 30

CHD (truncus arteriosis) hypoparathyroid facial abnormalities low T cells

Answer 30

congenital thymic aplasia | DiGerorge

Question 31

Recurrent Nisseria infections

Answer 31

Terminal complement deficiency (C5-C9)

Question 32

Boy chronic catalase + infections + nitroblue tetrazolium

Answer 32

Chronic Granulomatous Disease

Question 33

Eczema, thrombocytopenia x linked combined B and T cell deficiency

Answer 33

Wiskott Aldrich

Question 34

Agammaglobulinemia lymphopenia infant

Answer 34

SCID | By either adenosine deaminase deficiency or defective IL2 receptors

Question 35

``` Infant recurrent bacterial infections persistent neutrophilia absent pus delayed separation of the umbilical cord ```

Answer 35

Leukocyte adhesion deficiency

Question 36

Mechanism by which steroids cause low WBC?

Answer 36

glucocorticoid induced demargination and storage poor release of neutrophils

Question 37

What drugs can induce neutropenia?

Answer 37

Sulfa drugs | PTU

Question 38

Which antibodies are produced in delayed transfusion reactions?

Answer 38

anti-Kell and Duffy

Question 39

``` Post transfusion uticaria puritis wheezing fever ```

Answer 39

Allergic reaction | Type 1 hypersensitivity against plasma proteins in transfused blood

Question 40

``` Post transfusion Dyspnea bronchospasm hypotension resspiratory arrest ```

Answer 40

Anaphylactic reaction | IgA deficient patients after receiving blood

Question 41

Post transfusion fever, chilld within 12 hours no hemolysis

Answer 41

Febrile non hemolytic transfusion reaction | Type II- host antibodies against donor antigens and WBCs

Question 42

``` Post transfusion immediate fever hypotension flank pain brown urine immediate ```

Answer 42

Acute hemolytic transfusion reaction | ABO mismatch

Question 43

Post transfusion (1-2 weeks) jaundice slow hmeolysis

Answer 43

Delayed hemolytic transfusion reaction

Question 44

Shortness of air during transfusion | lung crackles

Answer 44

Volume overload

Question 45

``` Post transfusion fever dyspnea noncardiogenic pulmonary edema esp after FFP ```

Answer 45

transfusion associated acute lung injury (TRALI)