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Integrative > Immunology Review > Flashcards

Immunology Review Flashcards

1
Q

AE of cisplatin

A

Nephrotoxicity and acoustic nerve damage

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2
Q

AE of bleomycin/ busulfan

A

Pulmonary fibrosis

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3
Q

AE of vincristine

A

Peripheral neuropathy

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4
Q

AE of doxorubicin

A

Cardiotoxicity

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5
Q

AE of cyclophosphamide

A

hemorrhagic cystitis

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6
Q

AE of trastuzumab

A

CHF

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7
Q

Mechanism of trastuzumab

A

monocolnal antibody against HER-2

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8
Q

Disease that rituximab is used for

A

B cell neoplasms (NHL)

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9
Q

Mech of rituximab

A

antibody against CD-20

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10
Q

Mechanism of bevacizumab

A

Ab against VEGF

inhibits angiogenesis

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11
Q

Mechanism of Omalizumab

A

Anti-IGE

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12
Q

When is Omalizumab used

A

severe asthma

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13
Q

Mechanism of Infliximab

A

Anti-TNF alpha

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14
Q

When is inflixumab used

A

Chron’s, RA

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15
Q

When is abciximab used

A

some acute coronary syndromes

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16
Q

Mechanism of abciximab

A

Anti-glycoprotein IIB/IIIA

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17
Q

Type I Hypersensitivity

A 
preformed antibody
IgE mediated
immediate symptoms:
-allergy
-atopy
-anaphylaxis
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18
Q

Type II Hypersensitivity

A

cytotoxic reactions of antibody against cells or tissues:
Hemolytic anemia
Goodpastures

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19
Q

Type III Hypersensitivity

A 
antigen-antibody complex deposition in tissue:
Vasculitis
serum sickness
post-strep GN
Arthus reaction
20
Q

What is an Arthrus reaction

A

edema and skin necrosis caused by activation on complement

21
Q

Type IV Hypersensitivity

A 
T cell mediated
Delayed presentation:
- TB skin test
-contact dermatitis
-Graft v Host disease
22
Q

Antibody found in scleroderma

A

Anti-ScL-70, anti-topoisomerase 1

23
Q

Antibody in drug induced lupus

A

Anti-histone

24
Q

Antibody in Autoimmune hepatitis

A

Anti-smooth muscle

25
Q

Antibody in primary biliary cirrhosis

A

Anti-mitochondrial

26
Q

Antibody in Celiac’s

A

Anti-tissue transglutaminase

27
Q

Mechanism of hereditary angioedema

A

decreased C1 esterase inhibitor

28
Q

Infant boy (4-6 months)
encapsulated organism sepsis
absent B cells

A

X-linked (Bruton’s) agammaglobulinemia

29
Q 
Young adult
recurrent sinusitis, pneumonia, bonchiectasis
splenomegaly
malignancies
GI malacpsorbption
A

Common variable immunodeficiency (B and T cell deficiency)

30
Q

CHD (truncus arteriosis)
hypoparathyroid
facial abnormalities
low T cells

A

congenital thymic aplasia

DiGerorge

31
Q

Recurrent Nisseria infections

A

Terminal complement deficiency (C5-C9)

32
Q

Boy
chronic catalase + infections
+ nitroblue tetrazolium

A

Chronic Granulomatous Disease

33
Q

Eczema, thrombocytopenia
x linked
combined B and T cell deficiency

A

Wiskott Aldrich

34
Q

Agammaglobulinemia
lymphopenia
infant

A

SCID

By either adenosine deaminase deficiency or defective IL2 receptors

35
Q 
Infant
recurrent bacterial infections
persistent neutrophilia
absent pus
delayed separation of the umbilical cord
A

Leukocyte adhesion deficiency

36
Q

Mechanism by which steroids cause low WBC?

A

glucocorticoid induced demargination and storage poor release of neutrophils

37
Q

What drugs can induce neutropenia?

A

Sulfa drugs

PTU

38
Q

Which antibodies are produced in delayed transfusion reactions?

A

anti-Kell and Duffy

39
Q 
Post transfusion
uticaria 
puritis
wheezing
fever
A

Allergic reaction

Type 1 hypersensitivity against plasma proteins in transfused blood

40
Q 
Post transfusion
Dyspnea
bronchospasm
hypotension
resspiratory arrest
A

Anaphylactic reaction

IgA deficient patients after receiving blood

41
Q

Post transfusion
fever, chilld within 12 hours
no hemolysis

A

Febrile non hemolytic transfusion reaction

Type II- host antibodies against donor antigens and WBCs

42
Q 
Post transfusion
immediate
fever
hypotension
flank pain
brown urine
immediate
A

Acute hemolytic transfusion reaction

ABO mismatch

43
Q

Post transfusion (1-2 weeks)
jaundice
slow hmeolysis

A

Delayed hemolytic transfusion reaction

44
Q

Shortness of air during transfusion

lung crackles

A

Volume overload

45
Q 
Post transfusion
fever
dyspnea
noncardiogenic pulmonary edema
esp after FFP
A

transfusion associated acute lung injury (TRALI)

Integrative (15 decks)

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