Immuno USMLE Flashcards
a secondary lymphoid organ that has many afferents & 1 or more efferents. It is encapsulated, with trabeculae.
lymph node
fxs of lymph node (3)
1) filtration by macrophages
2) storage/proliferation of B and T cells
3) antibody production
this part of the lymph node is the site of B-cell localization and proliferation.
follicle
these follicules have pale central germinal centers and are active.
secondary follicles
this part of the lymph nodes consists of closely packed lymphocytes and plasma cells and sinuses that communicate with efferent lymphatic and contain reticular cells and macrophages
medulla
this part of the lymph node houses T cells. It is the region of the cortex between follicles and medulla. It contains high endothelial venules through which T and B cells enter from the blood. In extreme cellular immune response (i.e., viral) the this becomes greatly enlarged.
paracortex
paracortex is not well developed in pts with this syndrome
DiGeorge syndrome
this duct drains the right arm and right half of the head
right lymphatic duct
this duct drains the right arm and right half of the head
right lymphatic duct
this duct drains everything besides the right arm and right half of the head
thoracic duct
these are long vascular channels in red pulp with fenestrated “barrel hoop” basement membrane. Macrophages are found nearby.
sinusoids of the spleen
these cells are found in the periarterial lymphatic sheath (PALS) and in the red pulp of the pleen.
T cells
these cells are found in the follicles within the white pulp of the spleen
B cells
this is the site of T-cell maturation.
thymus
mneu: think of the Thymus as “finishing school” for T cells. They arrive immature and “dense” in the cortex; they are mature in the medulla.
the thymus is from the epithelium of this branchial pouch.
3rd
In the thymus, the cortex is dense with this type of T cells; while the medulla is pale with this type of T cells and epithelial reticular cells and Hassall’s corpuscles.
immature
mature
In the corticomedulary junction only T cells with MHC restriction are chosen, this is called?
then only T cells that are non-reactive to self are chosen.
what is this called
positive selection
negative selecton
this type of T cell produces IL-2 & gamma interfereon in order to activate macrophages and Tc cells
Th1 cells
this type of T cell produces IL-4 & IL-5 to help B cells make Ab
Th2 cells
B=2nd letter of the alphabet
State whether this is a fx of B (Ab mediated immunity) or T (Cell mediated immunity) cells:
Host defense against infection (opsinize bacteria, neutralize toxins & viruses)
Ab mediated immunity (B cells)
State whether this is a fx of B (Ab mediated immunity) or T (Cell mediated immunity) cells:
Host defense against Mycobacterium tuberculosis, virus infected cells, and fungi.
Cell mediated immunity (T cells)
State whether this is a fx of B (Ab mediated immunity) or T (Cell mediated immunity) cells:
Host defense against Mycobacterium tuberculosis, virus infected cells, and fungi.
Cell mediated immunity (T cells)
State whether this is a fx of B (Ab mediated immunity) or T (Cell mediated immunity) cells:
Allergy (e.g., hay fever, type I hypersensitivity)
B (Ab mediated immunity)
State whether this is a fx of B (Ab mediated immunity) or T (Cell mediated immunity) cells: Allergy to poison oak, type IV hypersensitivity
Cell-mediated immunity (T cells)