Biochem Mnemonics Flashcards

1
Q

Catabolism steps of branched chain amino acids.

A

“Truck hit the Ox to Death”

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2
Q

Essential amino acids.

A

“PVT. TIM HALL always argues, never tires”
Phenylalanine, Valine, Threonine, Tryptophan, Histidine, Arginine, Leucine, Lysine
(always ARGues = ARGinine, not Asparagine)
(never TIRes = not TYRosine, but tryptophan and threonine)

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3
Q

Names of types I - VI of Glycogen storage.

A
"Viagra Pills Cause A Major Hardon"
Von gierke's
Pompe's
Cori's
Anderson's
Mcardles's
Her's
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4
Q

Glycolysis steps.

A

“Goodness Gracious, Father Franklin Did Go By Picking Pumpkins (to) Prepare Pies”

Glucose, Glucose -6 -P, Fructose-6-P, Fructose-1,6-diP, Dihydroxyacetone-P, Glyceraldehyde-P, 1,3-Biphosphoglycerate, 3-Phosphoglycerate, 2-Phophoglycerate, Phosphoenolpyruvate (PEP), Pyruvate

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5
Q

Niacin deficiency syptoms.

A
the 4 D's
Diarrhea
Dermatitis
Dementia
Death (if untreated)
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6
Q

When is the Phosphorylation cascade active?

A

“In the “Ph”asting state, Phosphorylate.”

active when blood glucose is low

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7
Q

Type 1 glycogen storage disease.

A

“Type 1 = one (Von)”

as in Von Gierke’s disease

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8
Q

Does the Van den Bergh reaction (Jaundice test of indirect reacting bilirubin) involve conjugated or unconjugated bilirubin?

A

“Indirect reacting bilirubin = Unconjugated bilirubin”

both start with vowels

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9
Q

Symptoms of the Vit B3 (niacin, nicotinic acid) deficiency known as Pellagra.

A
"the 3 D's of pellagra"
Dermatitis
Diarrhea
Dementia
(note vit B(3) is the (3) D's
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10
Q

The common Coagulation pathway (the factors in order).

A

“10 + 5 - 2 = 13”

Factor X to Factor V to Factor II to Factor XIII

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11
Q

Symptoms of Fabry’s disease.

A

“FABRY’S”
Foam cells in glomeruli / Febrile episodes
Alpha galactosidase A deficiency / Angiokeratomas
Burning pain in extremities
Renal failure
YX genotype (male, X linked recessive)
Sphingolipidoses

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12
Q

In heme synthesis, what are the precursor amino acids?

A

“Dracula wants to Suck a Co-ed’s blood (think heme) with his Glystening teeth.”

Succinyl CoA and Glycine are precursor amino acids to pyrole rings (the basic unit of porphyrins and heme).

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13
Q

What causes a hemoglobin binding curve to shift right?

A
"CADET, face right!"
CO2
Acid
2,3 DPG (aka 2,3 BPG)
Exercise
Temperature
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14
Q

How are amino acids involved in Sickle cell anemia?

A

“HBS isn’t Very Good”

at Sixth position of HB beta chain, Valine is present instead of Glutamic acid

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15
Q

Position on the beta chain that is affected in Sickle cell anemia.

A

“SICKle cell is due to a amino Substitution at the SICKsth position”

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16
Q

Vitamin K dependent cofactors.

A

“Several Tend To Nicely Stop Clots”
factor VII, X, II, and IX
protein S and C

17
Q

Adrenaline mechanism.

A

“ABC of Adrenaline”

Adrenaline activates Beta receptors then increases Cyclic AMP

18
Q

Mechanism that Glucagon uses to increase blood glucose.

A

“Mr. Gluca has GONe to the cAMP to bring out some Glucose”

glucagon elevates blood glucose by using cAMP mechanism

19
Q

3 classic signs of Hyperglycemia.

A

“DKA”
Dehydrated
Ketoacidosis
Acetone breath

20
Q

Amino acid precursers for Creatine phosphate.

A
"Nice GAMs!"
Glycine
Arginine
Methionine
(gams are slang for women's legs)
21
Q

Amino acids forming AcetylCoA and AcetoacetylCoA.

A
"A Lighter Lease (A LyTr LeIs)"
A = AcetylCoA or AcetoacetylCoA
Ly = Lysine
Tr = Tryptophan
Le = Leucine
Is = Isoleucine
22
Q

Carbon monoxide’s target in the electron transport. chain.

A

“CO blocks CO”

Carbon monoxide blocks Cytochrome Oxidase

23
Q

Citric acid cycle components.

A

“Can I Keep Selling Sex For Money, Officer?”

Citrate, Isocitrate, alpha Kergluterate, Succinyl CoA, Succinate, Fumerate, Malate, Oxaloacetate

24
Q

Strongest DNA bonds.

A

“Crazy Glue”
Cytosine and Guanine (3 H bonds)
(A=T only has 2 H bonds and b/c it’s weaker this is where the RNA primer makes the initial break)

25
Q

In the electron transport chain, at which complex site is the Rotenone’s site of action?

A

“RotenONE is a site specific inhibitor of complex ONE”

26
Q

In which is there a change in Vmax / Km?

Competitive or Non-competitive inhibition

A

“Kompetitive - Km increases; no change in Vmax”

“Non-Kompetitive - No change in Km; but Vmax decreases”

27
Q

Functions of the Golgi complex.

A

“Golgi Distributes A SPAM”
Distributes proteins and lipids from ER
Add mannose onto specific lysosome proteins
Sulfation of sugars and selected tyrosine
Proteoglycan assembly
Add O-oligosugars to serine and threnonine
Modify N-ologasugars on asparagine

28
Q

Malate-asparate shuttle.

A

“MAD commute”
Malate in
Alpha-ketoglutarate and D (aspartate) out

29
Q

What 3 processes happen in both, the cytosol and mitochondria metabolic sites?

A

‘Use both arms to HUG”
Heme synthesis
Urea cycle
Gluconeogenesis

30
Q

Number of Na and K in and out in the Na/K pump.

A

song (Kiss him goodbye) - “Na Na Na Out, Na Na Na Out, K K Goes…Inside”
(pump moves 3 Na out, 2 K in)

31
Q

Amino acid precurser for Nitric oxide.

A

You yell “AAArg!” at the dentist, so he gives you Nitric Oxide for the pain.

32
Q

What is Pompe’s disease?

A

“Police = Po + Lys”

Pompe’s disease is a Lysosomal storage disease

33
Q

Products of complete oxidation of Pyruvate.

A
"4 Naked Fun, 3 Coeds + 1 Guy"
4 NADH
FADH
3 CO2
1 GTP
34
Q

Symptom of Tangier’s disease.

A

“Tangierene tonsils”

large orange tonsils