Immuno - Abs Flashcards
Dermatomyositis
Anti-Jo1
*Sjogren (dry eyes and parotid swelling)
Anti-Ro and anti-La
*CREST (Limited cutaneous scleroderma)
?tight lips lol
Anti-centromere
Diffuse scleroderma
Anti-topoisomerase/SCL70
Primary biliary cholangitis
Anti-mitochondrial
*Myasthenia gravis (weakness + ptosis/droopy lid)
Anti-Acetyl choline receptor
*Rheumatoid arthritis (Aches all over + joint stiffness +joint swelling + XR shows erosive joint changes)
Anti cyclic citrullinated peptide, rheumatoid factor
*Systemic Lupus Erythematosus
young person + pleuritic chest pain, joint pain
Anti nuclear antibodies (Smith, Ro, La, histones) and anti-double strand DNA antibodies // C3 and C4
*Wegener’s (Granulomatous polyangitis)
Involves upper and lower airways + kidneys
C-ANCA (Anti-PR3*) - cytoplasmic antineutrophil cytopalsmic antibodies
Churg-Strauss (eosinophilic granulomatous polyangitis)
P-ANCA (Anti-MPO) - perinuclear antineutrophil cytoplasmic antibodies
Microscopic polyangitis
P-ANCA (Anti-MPO) - perinuclear antineutrophil cytoplasmic antibodies
Primary sclerosing cholangitis
P-ANCA (Anti-MPO) - perinuclear antineutrophil cytoplasmic antibodies
Autoimmune hepatitis
Anti-smooth muscle, anti liver-kidney microsomal-1
Autoimmune pancreatitis
IgG4
Goodpasture’s disease
Anti-glomerular basement membrane (Type IV collagen)
Coeliac
Anti-tissue transglutaminase (Anti TtG antibody), anti-endomysial, anti- gliadin
T1DM
Anti pancreatic beta cell, anti-glutamic acid decarboxylase
Antiphospholipid syndrome
Anti-cardiolipin, lupus anticoagulant
Graves
Anti-TSH receptor
*Hashimoto’s
Anti-thyroperoxidase, anti-thyroglobulin
Pernicious anaemia
Anti-parietal cell, anti- intrinsic factor
Multiple sclerosis (muscle fatigue and double vision)
Anti-myelin basic protein, anti-proteolipid
Membranous glomerulonephritis
Anti phospholipase A2 receptor
Polymyositis
Anti-Jo1
