Immuno Flashcards
Coeliac disease associated HLA
DQ2
Scleroderma syx
Hard, thickening, shiny, tight skin
Syndrome associated with limited scleroderma
CREST syndrome C- calcinosis R- reynauds E- oesophageal dysmotility (GORD) S- sclerodactyly (thick skin fingers) T- telangiectasia
Goodpasture syndrome presentation
Haemoptysis (inflamm and bleeding in lungs)
Haematuria
SLE presentation
malar rash, photosensitivity, fatigue, arthritis, mouth ulcers
What type of hypersensitivity reaction is SLE?
Type 3
Which antibody is responsible for protecting against GI infx?
IgA
What is a subunit/component vaccine?
use of antigenic proteins
Example of subunit vaccines
HPV - capsid
What is a conjugate vaccine?
polysaccharide + protein to invoke a strong reaction, used against encapsulated bacteria
Example of a conjugate vaccine
NHS
Neisseria meningitidis
Haemophilus influenzae
Streptotoccus pneumonia
Which vaccination is not safe for HIV patients?
Yellow fever
What is a live attenuated vaccine?
Weakened live pathogens
Live attenuated vaccine examples
MMR, VZV, rotavirus, Yellow Fever
Which live attenuated vaccine is safe for HIV pts?
MMR
Which receptor does Ipilimumab (Rx for met melanoma) bind to?
CTLA4
Which MHC is most important when matching donors?
DR (>B>A)
What is an inactivated vaccine?
Destroyed pathogens or their components, not able to replicate
Inactivated vaccine example
Pertussis, influenza, rabies
What type are the COVID vaccines?
DNA/RNA
