Chempath - Biomarkers

Question 1

*Which/What enzyme if low, leads to hyperuricemia/rise in blood uric acid?

Answer 1

HGPRT

Question 2

*Which/What enzyme regulates the rate limiting step in haem biosynthesis pathway/of the blood?

Answer 2

ALA synthase (Aminolevulinic acid)

Question 3

*Which/what enzyme is raised in osteomalacia?

Answer 3

Alkaline phosphatase

Question 4

*Which/What enzyme is raised in mumps?

Answer 4

Amylase S
(elevated w any inflamm of salivary glands)

Question 5

*In Rhabdomyolysis, 1. which biomarker is likely to be raised? 2. What causes dark urine in rhabdo?

Answer 5

Creatine kinase

Myoglobin

Question 6

*Which enzyme would you expect to be raised in obstructive jaundice/biliary obstruction?

Answer 6

GGT – gamma-glutamyl transpeptidase

Question 7

*Swollen joint, needle-shaped aspirate with negative birefringence, what is the enzyme responsible

Answer 7

Xanthine Oxidase

Question 8

*What enzyme to confirm cardiac failure?

Answer 8

Brain Natriuretic Peptide (BNP)

Question 9

*What liver enzyme is raised in MI?

Answer 9

Aspartate aminotransferase (AST)

Question 10

*What enzyme is raised in Pagets?

Answer 10

Alkaline phosphatase

Question 11

*Temporal arteritis test which will help with diagnosis?

Answer 11

Erythrocyte sedimentation rate (ESR)