Immunity Review

Question 1

Describe the complement system (OILCAN)

Answer 1

Opsonization:
-opsonins bind to surface of bacteria marking them
-phagocytic cells bind to receptors increasing binding of opsonins
-C3b and C4b
Inflammation: mast cells in anaphylaxis (C3a, C4a, C5a)
Lysis: due to formation of MAC (C5b6789)
Chemotaxis: (C5a)
Agglutination: changes surface of bacteria making them sticky
Neutralization

Question 2

Describe B lymphocytes

Answer 2

involved in humoral immunity
Bone marrow
aka plasma cells
make antibodies in the form of immunoglobulins

Question 3

Describe T lymphocytes

Answer 3

95% of circulating lymphocytes
thymus
Cell-mediated immunity

Question 4

Describe differentiation of T cells

Answer 4

Precursors in bone marrow go to the thymus where they differentiate into CD8 or CD4