Immune system #1 Flashcards
inherited defense mechanisms
innate, nonspecific immunity
adaptive or specific immune response is a funciton of
lymphoctyes
How does the innate immne system distinguish between self and invading pathogens?
recognizing pathogen associated molecular patterns (PAMPS)
Common PAMPs
lipopolysaccharide found in gram negative bacteria and peptidoglycan in gram positive
Receptor proteins that recognize pamps
pathogen recognition receptors
group of pathogen recognition receptors that responds to LPS from bacteria
toll like receptors
Cell attractant molecules that recruit other immune cells
chemokines
cell growth and regulatory molecules
cytokines
receptors that activate the transcription of genes that promote defenses like autophagy
NOD like receptors
What system promotes the formation of antigen antibody complexes
complement system
Complement proteins are part of the _____ immune system
innate
Local inflammation produced when tissue damage causes necrosis exposes the immune system to
DAMPS danger associated molecular patterns (or damage)
T/F apoptosis generally does not provoke inflammation
true
another name for neutrophils
polymorphonuclear cells
cells of the mononuclear phagocyte system
monocytes, macrophages, dendritic cells
microglia of the brain are an example of
organ specific phagocytes
phagocytic cells of the liver
kupffer cells
immoble phagocytes within organs
fixed phagocytes
What organs sterilize the blood
liver and spleen
Chemokines promote
chemotaxis
What cells are the first to arrive at the site of an infection
neutrophils
the ability of WBS to squeeze through gaps of endothelial cells
extravasation or diapedesis
What signals “eat me” to macrophages?
phosphatidylserine
What coordinates skeletal muscle shivering for thermoregulation?
thermoregulatory control center in the hypothalamus