Immune Lecture Flashcards
1
Q
look at
A
pg 115-117
2
Q
C3a and C5a
A
inflammation
3
Q
C3b
A
opsoniation
4
Q
MAC
A
lysis of membrane
5
Q
humoral immunity
A
B cells - antibodies
6
Q
cell mediated immunity
A
against intracellular agents
-T cells
most common virus
7
Q
microbe
A
microscopic organism
8
Q
peptide
A
chain of AAs
9
Q
CD
A
cluster designation
cell surface molecules
-receptors or ligands, etc.
10
Q
MHC class II
A
CD 4
11
Q
MHC class I
A
CD 8
12
Q
bacterial infection
A
CD4
13
Q
virus infection
A
CD8
14
Q
interferon gamma
A
T helper cells cytotoxic T cells NK cells dendritic cells M0s
**activator of macrophages
15
Q
NK cells
A
cytotoxic cell in the innate immune system
-respond to virally infected cells
16
Q
allele
A
one of a number of alternative forms of gene at single locus
17
Q
langerhans cell
A
dendritic cell in skin and mucosa
18
Q
langhans cell
A
giant cells in granulomas
-formed by fusion of epitheliod cells (M0s)
19
Q
anaphylaxis
A
type I hypersensitivity
20
Q
allergy
A
type I hyper sensitivity
21
Q
immediate hypersensitivity
A
type I
IgE - release of vasoactive amines by mast cells (early phase)
late phase - recruitment of inflammatory cells
22
Q
antibody-mediated hypersensitivity
A
type II
IgG and IgM bound to antigen
23
Q
autoimmune hemolytic anemia
A
type II hypersensitivity
24
Q
goodpasture syndrome
A
type II hypersensitivity
25
immune-complex mediated hypersensitivity
type III
antigen/antibody complexes leads to complement activation
get fibrinoid necrosis
26
SLE
type III hypersensitivity
27
serum sickness
type III hypersensitivity
28
arthus rxn
type III hypersensitivity
29
T-cell mediated hypersensitivity
type IV
activated T lymphocytes
30
TB skin test
type IV hypersensitivity
31
contact dermatitis
type IV hypersensitivity
32
type I diabetes
type IV hypersensitivity
33
multiple sclerosis
type IV hypersensitivity
34
rheumatoid arthritis
type IV hypersensitivity
35
inflammatory bowel disease
type IV hypersensitivity
36
Rh incompatability
type II hypersensitivity
37
vasculitis by ANCA
wagners disease
type II
lung and kidney disease acutely - with hemoptysis
necrotizing vasaculitis
38
goodpasture syndrome
type II
antibody against alveolar and glomerular BM
39
acute rheumatic fever
streptococcal antigen antibody will attack the myocardial antigen
type II
40
rheumatoid arthritis
autoimmune
41
myasthenia gravis
antibody for acetylcholine receptors
type II
42
type I diabetes
antibodies against islet cells that produce insulin
type II
43
type II diabetes
have insulin
| -receptors have no avidity for the insulin - won't bind
44
graves disease
hyperthyroidism
antibodies for TSH receptor
type II
45
SLE
many organ system
anti-nuclear angibodies
type III
46
poststreptococcal glomerulonephritis
often in peds
type III
47
reactive arthritis
type III
yersinia bacteria
48
multiple sclerosis
type IV
common-in women**
-young caucasians
common chronic neuro disease
don't have antibodies - have a T cell response
-to myelin
49
guillain barre
ascending paralysis
after upper respiratory infection
do get antibodies against myelin
50
crohns
proximal bowel
51
ulcerative colitis
large bowel
52
pentadecylcatorchol
poison ivy
type IV
53
granuloma
with epithiloid histiocytes
don't need giant cells
TB is prototype
54
allergy
immune against exogenous substance
55
autoimmune
immune against endogenous substance
defined by:
1 - presence of immune reaction for specific self antigen
2 - evidence the rxn not secondary to tissue damage
3 - absence of another well defined cause
56
IgG bands
in multiple sclerosis
- not against the myelin
- not involved in the path process
57
look at table
6-7 in robbins
58
ankylosing spondylitis
fusion of adjacent bones
HLA B27 positive
59
HLA B27
associated with ankylosing spondylitis
60
SLE
multisystem autoimmune disease
-fever, injury to skin, joints, kidney, serosal membrane
predominantly women
-higher in blacks and hispanics
61
Dx of SLE
need 4 of 11 manifestations
```
malar rash
discoid rash
photosensitivity**
oral ulcer
arthritis
serositis
renal disorder
neuro disorder
hemo disorder**
immune disorder
antinuclear antibody
```
62
know for SLE
spectrum of antibodies and ANA categories
also etiology and pathogenesis
63
reticulocytosis
early in lineage of blood cells
64
know drugs involved with SLE
in book
65
anti ds-DNA and anti-Smith antibodies
likely SLE
66
only anti-histone antibodies
drug-induced LE
67
antibodies against DNA-topoisomerase I
systemic sclerosis
diffuse**
68
antibodies against centromeric proteins
limited scleroderma
CREST**
69
antibodies against ribonucleoproteins
sjogren syndrome
70
know for SLE
table 6-10
```
hematologic
arthritis
skin
fever
fatigue
renal disease
pleuritis myalgia pericarditis
endocarditis (libman sacks)
raynaud
```
71
most common glomerular problems with SLE
hypercellular
type IV - diffuse proliferative
-worst prognosis with renal failure
72
rheumatoid arthritis
specific antigen not known
cytokines damage synovial cells
can lead to pannus formation
-destruction of one, cartilage, fibrosis, ankylosis (fusion)
can see nodules all over body
-commonly in lung
73
CREST variant of scleroderma
limited scleroderma
74
CREST
```
calcinosis
raynauds
esophageal fibrosis
sclerodactylyl
telangiectesia
```
in vignette - not only scleroderma
need more info for limited scleroderma Dx
75
RNP Ag antibodies
mixed CT disease
-often symptoms of other autoimmune diseases
76
anticentromere Ab
limited scleroderma
77
DNA topoisomerase Ab
systemic diffuse scleroderma
78
Jo-1 antibodies
with proximal muscle weakness
inflammatory myopathy
79
histone Ab
drug induced LE
80
RNP Ab
sjogren syndrome
81
sjogren syndrome
involves salivary glands and lacrimal gland
-mononuclear infiltrate and epithelial proliferations
common in women
keratoconjunctivitis sicca
xerostomia
often seen in association with other autoimmune diseases
82
pure sjogrens
limited to head and neck
83
progressive systemic sclerosis
scleroderma
84
mixed CT disease
combination of SLE, scleroderma, polymyositis
page 226 in robbins
less than 4 of SLE with some of scleroderma, proxomal m. weakness
also look at antibody
