Immune Lecture Flashcards
look at
pg 115-117
C3a and C5a
inflammation
C3b
opsoniation
MAC
lysis of membrane
humoral immunity
B cells - antibodies
cell mediated immunity
against intracellular agents
-T cells
most common virus
microbe
microscopic organism
peptide
chain of AAs
CD
cluster designation
cell surface molecules
-receptors or ligands, etc.
MHC class II
CD 4
MHC class I
CD 8
bacterial infection
CD4
virus infection
CD8
interferon gamma
T helper cells cytotoxic T cells NK cells dendritic cells M0s
**activator of macrophages
NK cells
cytotoxic cell in the innate immune system
-respond to virally infected cells
allele
one of a number of alternative forms of gene at single locus
langerhans cell
dendritic cell in skin and mucosa
langhans cell
giant cells in granulomas
-formed by fusion of epitheliod cells (M0s)
anaphylaxis
type I hypersensitivity
allergy
type I hyper sensitivity
immediate hypersensitivity
type I
IgE - release of vasoactive amines by mast cells (early phase)
late phase - recruitment of inflammatory cells
antibody-mediated hypersensitivity
type II
IgG and IgM bound to antigen
autoimmune hemolytic anemia
type II hypersensitivity
goodpasture syndrome
type II hypersensitivity
immune-complex mediated hypersensitivity
type III
antigen/antibody complexes leads to complement activation
get fibrinoid necrosis
SLE
type III hypersensitivity
serum sickness
type III hypersensitivity
arthus rxn
type III hypersensitivity
T-cell mediated hypersensitivity
type IV
activated T lymphocytes
TB skin test
type IV hypersensitivity
contact dermatitis
type IV hypersensitivity
type I diabetes
type IV hypersensitivity
multiple sclerosis
type IV hypersensitivity
rheumatoid arthritis
type IV hypersensitivity
inflammatory bowel disease
type IV hypersensitivity
Rh incompatability
type II hypersensitivity
vasculitis by ANCA
wagners disease
type II
lung and kidney disease acutely - with hemoptysis
necrotizing vasaculitis
goodpasture syndrome
type II
antibody against alveolar and glomerular BM
acute rheumatic fever
streptococcal antigen antibody will attack the myocardial antigen
type II
rheumatoid arthritis
autoimmune
myasthenia gravis
antibody for acetylcholine receptors
type II
type I diabetes
antibodies against islet cells that produce insulin
type II
type II diabetes
have insulin
-receptors have no avidity for the insulin - won’t bind
graves disease
hyperthyroidism
antibodies for TSH receptor
type II
SLE
many organ system
anti-nuclear angibodies
type III
poststreptococcal glomerulonephritis
often in peds
type III
reactive arthritis
type III
yersinia bacteria
multiple sclerosis
type IV
common-in women**
-young caucasians
common chronic neuro disease
don’t have antibodies - have a T cell response
-to myelin
guillain barre
ascending paralysis
after upper respiratory infection
do get antibodies against myelin
crohns
proximal bowel
ulcerative colitis
large bowel
pentadecylcatorchol
poison ivy
type IV
granuloma
with epithiloid histiocytes
don’t need giant cells
TB is prototype
allergy
immune against exogenous substance
autoimmune
immune against endogenous substance
defined by:
1 - presence of immune reaction for specific self antigen
2 - evidence the rxn not secondary to tissue damage
3 - absence of another well defined cause
IgG bands
in multiple sclerosis
- not against the myelin
- not involved in the path process
look at table
6-7 in robbins
ankylosing spondylitis
fusion of adjacent bones
HLA B27 positive
HLA B27
associated with ankylosing spondylitis
SLE
multisystem autoimmune disease
-fever, injury to skin, joints, kidney, serosal membrane
predominantly women
-higher in blacks and hispanics
Dx of SLE
need 4 of 11 manifestations
malar rash discoid rash photosensitivity** oral ulcer arthritis serositis renal disorder neuro disorder hemo disorder** immune disorder antinuclear antibody
know for SLE
spectrum of antibodies and ANA categories
also etiology and pathogenesis
reticulocytosis
early in lineage of blood cells
know drugs involved with SLE
in book
anti ds-DNA and anti-Smith antibodies
likely SLE
only anti-histone antibodies
drug-induced LE
antibodies against DNA-topoisomerase I
systemic sclerosis
diffuse**
antibodies against centromeric proteins
limited scleroderma
CREST**
antibodies against ribonucleoproteins
sjogren syndrome
know for SLE
table 6-10
hematologic arthritis skin fever fatigue renal disease pleuritis myalgia pericarditis endocarditis (libman sacks) raynaud
most common glomerular problems with SLE
hypercellular
type IV - diffuse proliferative
-worst prognosis with renal failure
rheumatoid arthritis
specific antigen not known
cytokines damage synovial cells
can lead to pannus formation
-destruction of one, cartilage, fibrosis, ankylosis (fusion)
can see nodules all over body
-commonly in lung
CREST variant of scleroderma
limited scleroderma
CREST
calcinosis raynauds esophageal fibrosis sclerodactylyl telangiectesia
in vignette - not only scleroderma
need more info for limited scleroderma Dx
RNP Ag antibodies
mixed CT disease
-often symptoms of other autoimmune diseases
anticentromere Ab
limited scleroderma
DNA topoisomerase Ab
systemic diffuse scleroderma
Jo-1 antibodies
with proximal muscle weakness
inflammatory myopathy
histone Ab
drug induced LE
RNP Ab
sjogren syndrome
sjogren syndrome
involves salivary glands and lacrimal gland
-mononuclear infiltrate and epithelial proliferations
common in women
keratoconjunctivitis sicca
xerostomia
often seen in association with other autoimmune diseases
pure sjogrens
limited to head and neck
progressive systemic sclerosis
scleroderma
mixed CT disease
combination of SLE, scleroderma, polymyositis
page 226 in robbins
less than 4 of SLE with some of scleroderma, proxomal m. weakness
also look at antibody
