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PBD I Exam 2 > Immune Lecture > Flashcards

Immune Lecture Flashcards

1
Q

look at

A

pg 115-117

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2
Q

C3a and C5a

A

inflammation

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3
Q

C3b

A

opsoniation

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4
Q

MAC

A

lysis of membrane

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5
Q

humoral immunity

A

B cells - antibodies

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6
Q

cell mediated immunity

A

against intracellular agents
-T cells

most common virus

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7
Q

microbe

A

microscopic organism

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8
Q

peptide

A

chain of AAs

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9
Q

CD

A

cluster designation

cell surface molecules
-receptors or ligands, etc.

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10
Q

MHC class II

A

CD 4

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11
Q

MHC class I

A

CD 8

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12
Q

bacterial infection

A

CD4

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13
Q

virus infection

A

CD8

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14
Q

interferon gamma

A 
T helper cells
cytotoxic T cells
NK cells
dendritic cells
M0s

**activator of macrophages

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15
Q

NK cells

A

cytotoxic cell in the innate immune system

-respond to virally infected cells

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16
Q

allele

A

one of a number of alternative forms of gene at single locus

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17
Q

langerhans cell

A

dendritic cell in skin and mucosa

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18
Q

langhans cell

A

giant cells in granulomas

-formed by fusion of epitheliod cells (M0s)

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19
Q

anaphylaxis

A

type I hypersensitivity

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20
Q

allergy

A

type I hyper sensitivity

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21
Q

immediate hypersensitivity

A

type I

IgE - release of vasoactive amines by mast cells (early phase)

late phase - recruitment of inflammatory cells

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22
Q

antibody-mediated hypersensitivity

A

type II

IgG and IgM bound to antigen

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23
Q

autoimmune hemolytic anemia

A

type II hypersensitivity

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24
Q

goodpasture syndrome

A

type II hypersensitivity

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25
Q

immune-complex mediated hypersensitivity

A

type III

antigen/antibody complexes leads to complement activation

get fibrinoid necrosis

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26
Q

SLE

A

type III hypersensitivity

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27
Q

serum sickness

A

type III hypersensitivity

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28
Q

arthus rxn

A

type III hypersensitivity

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29
Q

T-cell mediated hypersensitivity

A

type IV

activated T lymphocytes

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30
Q

TB skin test

A

type IV hypersensitivity

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31
Q

contact dermatitis

A

type IV hypersensitivity

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32
Q

type I diabetes

A

type IV hypersensitivity

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33
Q

multiple sclerosis

A

type IV hypersensitivity

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34
Q

rheumatoid arthritis

A

type IV hypersensitivity

35
Q

inflammatory bowel disease

A

type IV hypersensitivity

36
Q

Rh incompatability

A

type II hypersensitivity

37
Q

vasculitis by ANCA

A

wagners disease
type II

lung and kidney disease acutely - with hemoptysis

necrotizing vasaculitis

38
Q

goodpasture syndrome

A

type II

antibody against alveolar and glomerular BM

39
Q

acute rheumatic fever

A

streptococcal antigen antibody will attack the myocardial antigen

type II

40
Q

rheumatoid arthritis

A

autoimmune

41
Q

myasthenia gravis

A

antibody for acetylcholine receptors

type II

42
Q

type I diabetes

A

antibodies against islet cells that produce insulin

type II

43
Q

type II diabetes

A

have insulin

-receptors have no avidity for the insulin - won’t bind

44
Q

graves disease

A

hyperthyroidism

antibodies for TSH receptor

type II

45
Q

SLE

A

many organ system

anti-nuclear angibodies

type III

46
Q

poststreptococcal glomerulonephritis

A

often in peds

type III

47
Q

reactive arthritis

A

type III

yersinia bacteria

48
Q

multiple sclerosis

A

type IV

common-in women**
-young caucasians

common chronic neuro disease

don’t have antibodies - have a T cell response
-to myelin

49
Q

guillain barre

A

ascending paralysis
after upper respiratory infection

do get antibodies against myelin

50
Q

crohns

A

proximal bowel

51
Q

ulcerative colitis

A

large bowel

52
Q

pentadecylcatorchol

A

poison ivy

type IV

53
Q

granuloma

A

with epithiloid histiocytes

don’t need giant cells

TB is prototype

54
Q

allergy

A

immune against exogenous substance

55
Q

autoimmune

A

immune against endogenous substance

defined by:
1 - presence of immune reaction for specific self antigen
2 - evidence the rxn not secondary to tissue damage
3 - absence of another well defined cause

56
Q

IgG bands

A

in multiple sclerosis

  • not against the myelin
  • not involved in the path process
57
Q

look at table

A

6-7 in robbins

58
Q

ankylosing spondylitis

A

fusion of adjacent bones

HLA B27 positive

59
Q

HLA B27

A

associated with ankylosing spondylitis

60
Q

SLE

A

multisystem autoimmune disease

-fever, injury to skin, joints, kidney, serosal membrane

predominantly women
-higher in blacks and hispanics

61
Q

Dx of SLE

A

need 4 of 11 manifestations

malar rash
discoid rash
photosensitivity**
oral ulcer
arthritis
serositis
renal disorder
neuro disorder
hemo disorder**
immune disorder
antinuclear antibody
62
Q

know for SLE

A

spectrum of antibodies and ANA categories

also etiology and pathogenesis

63
Q

reticulocytosis

A

early in lineage of blood cells

64
Q

know drugs involved with SLE

A

in book

65
Q

anti ds-DNA and anti-Smith antibodies

A

likely SLE

66
Q

only anti-histone antibodies

A

drug-induced LE

67
Q

antibodies against DNA-topoisomerase I

A

systemic sclerosis

diffuse**

68
Q

antibodies against centromeric proteins

A

limited scleroderma

CREST**

69
Q

antibodies against ribonucleoproteins

A

sjogren syndrome

70
Q

know for SLE

A

table 6-10

hematologic
arthritis
skin
fever
fatigue
renal disease
pleuritis myalgia pericarditis
endocarditis (libman sacks)
raynaud
71
Q

most common glomerular problems with SLE

A

hypercellular
type IV - diffuse proliferative
-worst prognosis with renal failure

72
Q

rheumatoid arthritis

A

specific antigen not known

cytokines damage synovial cells

can lead to pannus formation
-destruction of one, cartilage, fibrosis, ankylosis (fusion)

can see nodules all over body
-commonly in lung

73
Q

CREST variant of scleroderma

A

limited scleroderma

74
Q

CREST

A 
calcinosis
raynauds
esophageal fibrosis
sclerodactylyl
telangiectesia

in vignette - not only scleroderma

need more info for limited scleroderma Dx

75
Q

RNP Ag antibodies

A

mixed CT disease

-often symptoms of other autoimmune diseases

76
Q

anticentromere Ab

A

limited scleroderma

77
Q

DNA topoisomerase Ab

A

systemic diffuse scleroderma

78
Q

Jo-1 antibodies

A

with proximal muscle weakness

inflammatory myopathy

79
Q

histone Ab

A

drug induced LE

80
Q

RNP Ab

A

sjogren syndrome

81
Q

sjogren syndrome

A

involves salivary glands and lacrimal gland

-mononuclear infiltrate and epithelial proliferations

common in women

keratoconjunctivitis sicca
xerostomia

often seen in association with other autoimmune diseases

82
Q

pure sjogrens

A

limited to head and neck

83
Q

progressive systemic sclerosis

A

scleroderma

84
Q

mixed CT disease

A

combination of SLE, scleroderma, polymyositis

page 226 in robbins

less than 4 of SLE with some of scleroderma, proxomal m. weakness

also look at antibody

PBD I Exam 2 (18 decks)

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