Cancer I Lecture Flashcards by Matt Stanton

hamartoma

disorganized growth of tissue that is indigenous to the site

ex/ lung has cartilage tumors

How well did you know this?

Not at all

Perfectly

choristoma

disorganized tissue growth of something not indigenous to tissue

ex/ gastric tissue in pancreas

How well did you know this?

Not at all

Perfectly

pheochromocytoma

adrenal

10% tumor

How well did you know this?

Not at all

Perfectly

parenchma

cellular component of neoplasm

How well did you know this?

Not at all

Perfectly

stroma

supportive cell component

typically mesoderm (mesenchyme)

How well did you know this?

Not at all

Perfectly

mucinous adenocarcinoma

can cause endocarditis

cause hypercoagulable state

How well did you know this?

Not at all

Perfectly

common young men solid tumor

testicular

-seminoma

How well did you know this?

Not at all

Perfectly

hCG

from choriocarcinoma

How well did you know this?

Not at all

Perfectly

types of sarcoma

CT - fibroconnective, adipose, cartilage, bone

endothelium - blood or lymph

synovium

mesothelium

brain coverings

bone marrow, nodes

smooth m

skeletal m

How well did you know this?

Not at all

Perfectly

lymphoma

malignant

How well did you know this?

Not at all

Perfectly

mesothelioma

malignant

How well did you know this?

Not at all

Perfectly

melanoma

malignant

How well did you know this?

Not at all

Perfectly

seminoma

malignant

How well did you know this?

Not at all

Perfectly

immature teratoma

malignant

How well did you know this?

Not at all

Perfectly

hamartoma

not a neoplasm

-mass of cells normally present in tissue in disorganized manner

How well did you know this?

Not at all

Perfectly

pleomorphic adenoma

mixed benign tumor of salivary gland

How well did you know this?

Not at all

Perfectly

blast-

generally a childhood

How well did you know this?

Not at all

Perfectly

wilms tumor

nephroblastoma

-from renal anlage - precursor to kidney

How well did you know this?

Not at all

Perfectly

grading

by pathologist

-differentiation of tumor

How well did you know this?

Not at all

Perfectly

staging

by oncologist

-depth of invasion or metastasis

How well did you know this?

Not at all

Perfectly

TNM

size of tumor
nodes
metastasis?

anaplasia

appearance of cell - mainly nucleus

breast carcinoma

most malignancy - from the the ductal component

stromal component - not malignant

differentiation

degree to which neoplasm resembles tissue of origin

less differentiated - more malignant

levels of differentiation

well moderately poor - cellular anaplasia undifferentiated

scirrhous

rock hard tumor

desmoplasia

lots of collagen

anaplasia

loss of cell structure or function key to determine grade of tumor it is the stem cells that de-differentiate, not the mature cells

metaplasia

replace of one type of cell by another not pre-malignant

T-ICs

tumor initiating cells | -can indefinitely maintain tumor growth

carcinoma in situ

dyspalsia in entire thickness of epithelium

higher number of mitotic figure

finding in malignancies

as tumor population expands

higher percentage of tumor cells leave replicative pool

benign tumors

often have capsule - of CT

tumors can do what

impinge adjacent structures functional activity bleeding and infection with ulceration cachexia/wasting rupture or infarction

paraneoplastic syndromes

tumor cells themselves secrete hormone

grading

differentiation | -pathologist

staging

oncologist | -metastasis, infiltration

dermoid cyst

mature teratoma

AFP

secreted by yolk sac tumors switches to albumin after birth

CEA

colon carcinoma does not indicate malignancy

CA-125

biomarker for ovarian cancer

PSA

prostate specific antigen | -used to monitor after diagnosis

IgG

marker seen with B cell lymphoma

dermoid cyst

mature teratoma

95% of malignancies

are epithelial | -carcinoma

small cell carcinoma of lung

central - hilar region squamous cell

leukoplakia

white patches in mouth

uterine leiomyoma

not encapsulated - but are compressed with well-defined cleavage plane

local invasion

implies malignant neoplasm