Immune Articles 2017-2019 Flashcards
2019 JAVMA What is precursor targeted IMA and how long did it take for immunosuppression to be effective
Non-regenerative anemia with immunospression at the level of the bone marrow
~4 weeks for regenerative response
2019 JVIM consensus for IMHA Diagnosis: What does lack of regeneration indicated
30% of IMHA are not regenerative at diagnosis
2019 JVIM consensus for IMHA Diagnosis: Why might a PCV be more valuable for diagnosis than HCT
HCT (calculated) is unreliable with agglutination
2019 JVIM consensus for IMHA Diagnosis: what are the signs of hemolysis and how many are needed to support IMHA
> 2 signs Spherocytes (dogs only) Positive saline agglut with out washing positive coombs or flow cytometry -- positive SAT that persists after washing
2019 JVIM consensus for IMHA Diagnosis: What are signs of hemolysis and how many are needed to support IMHA
> 1 sign hyperbilirubinemia (hyperbilirubinuria) with out concurrent disease Hemoglobinemia Hemoglobinuria Erythrocyte ghosts
2019 JVIM consensus for IMHA Diagnosis: What infectious agents are likely associated with IMHA in dogs and cats
Babesia gibosoni - dogs
babesia felis- cats
mycoplasma haemofelis- cats
2019 JVIM consensus for IMHA Diagnosis: What testing is recommended for dogs and cats (infectious)
Dogs: Babesia gibosoni, D. Immitis; other endemic infections
Cats: Babesia felis (endemic areas only); M. Haemofelis, FeLV/FIV
2019 JVIM consensus for IMHA Treatment in dogs: What is the preferred fluid to improve oxygen delivery?
pRBCs > whole blood»_space;» bovine hemoglobin solutions
2019 JVIM consensus for IMHA Treatment in dogs: What are reasons that bovine hemoglobin solutions not recommended unless only available
scavange nitric oxide potentially activating platelets causing vasoconstriction which increases risk of hypertension
Greater colloid osmotic pressure than RBCs
2019 JVIM consensus for IMHA Treatment in dogs: What is the first line recommendation for immunosuppression
Prednisone 2-3 mg/kg/day or > 25 kg 50-60 mg/m2/day
2019 JVIM consensus for IMHA Treatment in dogs: When is IV immunglobin recommended
If 2 or more immunosuppressives and failing to respond (5-7 days) as a salvage measure
May decrease time to normal PCV, and Decrease transfusion requirements
2019 JVIM consensus for IMHA Treatment in dogs: When is thromboprophylaxis recommended
All as long as platelets > 30k/mcL (some 50K)
JVIM 2019 What were findings that were common in animals positive for Erlichia Ewingii
Renal disease, IMHA, Protienuria
Infects granulocytes
JVIM 2019 C6 borrelia positive dogs were more likely to have what findings
Immune complex glomerulonephritis (on all histo)
thrombocytopenia, azotemia, hyper phosph, anemia, neutrophillia
Hematuria, glucosuria, pyuria
JVIM 2019 What treatment showed success in 3 dogs with pythosis
Itraconazole, terbinafine, prednisone- anti-inflammatory
JVIM 2019 How did a POC for cryptococcus do compared to a agglutination test
as good as.