Fungal

Question 1

Blasto geography

Answer 1

Mississippi Ohio river valley eastern us

Question 2

Blasto Mode of infection

Answer 2

Inhalation as a pro gating yeast. Blood spread. Does not spread via respiratory as the yeast gets to big. Rare to be a focal skin lesion.

Question 3

Blasto signalment

Answer 3

Males 1-5 years (2 yrs)

Larger breed and sporting breeds

Question 4

Blasto signs

Answer 4

Skin eyes brain bone lymph nose; lung; external nares

Question 5

Blasto testing blood work abnormalities

Answer 5

Hypercalcemia hyperglobulinnemia, anemia mild, leukocytosis

Question 6

Blasto diagnosis

Answer 6

Gold standard - find organism any stain okay.

LN aspirant and draining lesion > 50%

Question 7

AGID Blasto

Answer 7

41-90 sensitivity

90-100 specitificty measures antibodies

Question 8

Ag EIA blasto

Answer 8

93.5 known will be positive. Antigen ursine or serum can do CSF

Question 9

Amphotericin b mechanism of action

Answer 9

Lipholic; also antibiotic. Binds to ergosterol. Forms a pore tha t allows electrolytes

Poorly absorbed across skin and gut

Question 10

Ampi b toxicity

Answer 10

Nephrotoxic.
To avoid improve renal blood flow

Lipid base have less toxicity but are less absorbed. Good for CNS disease

Question 11

Dosing of ampi B

Answer 11

Give every other day in cats and dogs

Question 12

Azole moa

Answer 12

Block ergostol synthesis and inhibits cell wall formation

Question 13

Itraconazole

Answer 13

Does not get csf
More selective for fungal. Preferred med
5 mg/kg/day 74% response
Preferred name brand. Not excreted in the urine

Question 14

Recurrence rate for blasto

Answer 14

20%

Question 15

Ketocinazole

Answer 15

Absorption better go tract. Does not penetrate cns, ocular, seminal

Question 16

Adverse effects of -azoles

Answer 16

Hepatotoxic- increase of liver enzyme ALT. If stop medication expect to see resolution.
Ulcerative dermatitis

Question 17

Combo therapy for fungal disease

Answer 17

Azole & terbinfjn

Azole and ampho

Question 18

Terbenifine

Answer 18

Decreases terbinfine synthesis

Don’t use as a sole therapy

Question 19

Blasto prognosis

Answer 19

Severity of lung disease. CNS diseas.

Die within the first week of therapy 50%
Worsening of clinical signs do. Or get worse.
Steroids may be initiated to be considered; may have imperoved radiographs