Hypersensitivity Flashcards
What antibody mediated in Type 1 hypersensitivity?
IgE
What antibody mediated in Type 2 hypersensitivity?
IgG/IgM
What antibody mediated in Type 3 hypersensitivity?
IgG/IgM
The release of Cytokines is a mechanism of what type of hypersensitivity?
Type 4 hypersensitivity
Allergic and anaphylactic reactions is associated in what type of hypersensitivity?
Type 1 hypersensitivity
Cytolysis due to antibodies & complement is included in what hypersensitivity?
Type 2 hypersensitivity
What hypersensitivity that includes immune complex deposition?
Type 3 hypersensitivity
What is the most sensitive test, in vivo for hypersensitivity, that uses a needle to introduce a drop of allergen into the upper layer of skin of the forearm or back?
Percutaneous/Prick/Puncture Test
A positive result in the Puncture/Percutaneous Test demonstrates what?
Wheal & Flare (3-4 mm)
In the Intradermal test, after 15-20 mins. a positive result should show what characteristic?
Erythema & Wheal formation
How much antigen is administered to the inner forearm or upper arm of the patient in INtradermal Test?
0.01-0.05 mL
RAST (Radioallergosorbent test) is used to measure what specific immunoglobulin?
IgE
RIST (Radioimmunosorbent test) uses a radiolabeled IgE and what for a limited Ab binding site?
Patient IgE
Polyclonal AHG contains Abs directed to what substances?
IgG, C3b, C3d
Monoclonal AHG determines whether it is ____, _______, _______
IgG, C3b, C3d
How much time is needed to check for the redness in Patch testing?
48 hours
Positive result in Patch Testing ?
Red with Papules
How many units of PPD is injected intrademally using a syringe or fine needle in Mantoux method?
0.1 mL of 5 tuberculin units of PPD
Mantoux method is examined between what hours?
48-72 hrs (2-3d)
A positive Mantoux test shows what reaction?
> /= 5mm - HIV patient
/= 10mm - immigrants
/= 15 mm - individuals without risk factors
