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Immunoserology > Adaptive Immune System > Flashcards

Adaptive Immune System Flashcards

1
Q

They modulate inflammation & immunity by regulating growth, mobility, & differentation of lymphoid cells

A

Interleukins

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2
Q

For inflammation, fever, initiation of acute phase response, regulation of hematopoiesis IL

A

IL-1

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3
Q

Growth & proliferation of B & T cells IL

A

IL-2

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4
Q

NK and Tc ell activation & proliferation

A

IL-2

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5
Q

Hematopoiesis IL

A

IL-3

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6
Q

“B cell growth factor 1”, Th2 differentiation, B cells to switch to IgE production (isotype switching)

A

IL-4

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7
Q

“B cell growth factor 2”,
eosinophil generation & activation
B cell & T cell growth & differentiation

A

IL-5

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8
Q

Initiation of the acute phase response
activation of B cell to plasma cells

A

IL-6

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9
Q

Stimulates proliferation of lymphoid progenitors

A

IL-7

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10
Q

Potent stimulator of neutrophils in chemotaxis

A

IL-8

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11
Q

Activates “respiratory burst” & release of specific azurophilic granule contents

A

IL-8

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12
Q

PROLIFERATION OF T CELLS, THYMOCYTES, MAST CELLS

A

IL-9

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13
Q

Inhibition of antigen presentation
inhibition of interferon gamma
suppression of Th2 cells

A

IL-10

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14
Q

Inhibition of B & t cell proliferation
induction of IgA
Inhibition of macrophages

A

TGF-B

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15
Q

Proinflammatory cytokines

A

IL-1, 6, 8, 15, 18, TNF-a

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16
Q

Anti-inflammatory cytokines

A

IL-10, 13, 35, TGF-b

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17
Q

Where is the site of B cell maturation?

A

Bone Marrow

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18
Q

Where is the site of T cell maturation?

A

Thymus

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19
Q

Where were the B & T cell produced?

A

Bone Marrow

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20
Q

Progenitor cells from BM migrate to the thymus and differentiate under the influence of ______?

A

Thymosin

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21
Q

What are the Secondary Lymphoid organs?

A

CLMS

CALT
Lymph node
MALT
Spleen

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22
Q

This traps antigen entering from subcutaneous

A

Lymph nodes

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23
Q

This traps Ag entering from blood

A

Spleen

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24
Q

Cells that is Ab mediated, primarily against bacterial infection

A

B cells

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25
Cells that are cell-mediated, against viral, fungal tumor, and graft rejection
T cells
26
Location of Bcells in the Lymph nodes
Cortex
27
Location of B cells in the Spleen
Follicular area
28
Where is the location of T cells in the lymph nodes?
Paracortex
29
Where is the location of the t cells in the spleen?
PALS (Perinuclear Assoc. Lymphoid Sheath)
30
What are the CD MArkers of B cells?
CD 19 CD 20 CD 21 CD 25 CD 40 MHC 1 &2
31
CD 19 marker in B cells is what?
a pan marker
32
CD 20 in b cells is what?
Ion channel
33
CD 21 in b cells is associated with what?
EBV, C3D
34
CD 25 in b cells is present in where?
activated b cell
35
CD 40 in b cells is responsible for what process?
isotype switching & memory cell formation
36
B CELLS percentage life span in the BM and PB
BM: 90% PB: 10-15% months to years
37
What are the B CELL mitogens
LPS, SPA, Pokeweed mitogen
38
What are the T cell mitogens?
PHA, Concanavalin A, pokeweed mitogen
39
What are the t cell cd markers?
CD 2, 3, 4, 8
40
T cells are present in spleen in what area?
PALS
40
T cells are present in lymph nodes in what area?
Paracortex
41
CD2 T cell CD marker is for what?
Classical marker for T cell (rosette formation)
42
CD 3 t cell CD marker is for?
TCR complex
43
CD4 T cell CD marker is found in what type of MHC complex?
MHC II
44
T cell identification uses sheep rbcs forming what formation?
Rosette formation
45
CD8 T cell CD marker is found in MHC what type?
MHC I
46
T cells precentage in BM and PB?
BM: 10% PB: 80% others: 5-10% (NK cells)
47
What is the GOLD STANDARD for the identifiucation of B and T cells?
FLOW CYTOMETRY
48
What test uses sheep rbcs that binds to the CD2 marker forming Rosette formation?
Rosette test
49
Rosette test identifies what type of cell?
T cells
50
What test is used for lymphocyte separation?
Ficoll hypaque
51
What is the SG in Ficoll Hypaque test?
1.077 - 1.114
52
What sample is used for the Lymphocyte separation test?
Heparinized/ACD or defibrinated blood
53
What is the normal CD4:CD8 ratio?
2:1
54
What is the CD4:CD8 ratio during HIV?
1:2
55
What the is the normal CD4 conc.?
500 - 1,200 /uL
56
What is the CD4 conc during AIDS?
<200 /uL
57
What is the CD marker for Th cells?
CD4
58
What is the CD marker for Tc cells?
CD8
59
What is the CD marker for Ts cells?
CD8
60
What is the CD marker for Tm cells?
CD4. CD8
61
What is the CD marker for Treg cells?
CD3, CD4, CD25
62
These T cells limit the immune response
Treg, Ts
63
A T cell that do surveillance and responsible for the anamnestiuc response
Tm (memory T cell)
64
A t cell that secretes IL2, an d activates B cells into plasma cells
T helper cells (50-60%)
65
A t cell that destroy infected cells, releases perforins and granzymes and secrete IFN-y
Cytotoxic t cells (20-25%)
66
B cell maturation: Pro B cell - presence of ?
CD19, CD45R
67
B cell maturation: Pre B cell-
IgM heavy chain + Light chain
68
Heavy chain rearrangement at chromosome 14 is done in what stage of B cell maturation?
Pro B cell
69
Light chain rearrangement at kappa and lambda was done in what stage of B cell maturation?
Pre B cell
70
Naive/Immature B cells has what CD markers?
CD 19, 20, 21, 35
71
The presence of surface IgM is on what stage of B cell maturation?
Immature B cell
72
Mature B cell has what Immunoglobulins?
sIgM, sIgD
73
Activated B cells has what CD marker?
CD25
74
What stage of b cell maturation produces antibodies?
Plasma cells
75
(T cell maturation) Double negative T lymphocyte:
(-) CD4, CD8 (+) CD2
76
(T cell maturation) Double positive T lymphocyte:
(+) CD4, CD8
77
Stage in t cell maturation where only the T cells with both markers survive
Positive Selection
78
What stage in t cell maturation where the cells with strong reaction to self markers are deleted?
Negative selection
79
(T cell maturation) Clonal expansion of what?
Double Positive T cells
80
What is the last stage of T cell maturation?
Single positive T Lymphocyte
81

Immunoserology (21 decks)

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