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Immunoserology > Adaptive Immune System > Flashcards

Adaptive Immune System Flashcards

1
Q

They modulate inflammation & immunity by regulating growth, mobility, & differentation of lymphoid cells

A

Interleukins

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2
Q

For inflammation, fever, initiation of acute phase response, regulation of hematopoiesis IL

A

IL-1

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3
Q

Growth & proliferation of B & T cells IL

A

IL-2

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4
Q

NK and Tc ell activation & proliferation

A

IL-2

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5
Q

Hematopoiesis IL

A

IL-3

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6
Q

“B cell growth factor 1”, Th2 differentiation, B cells to switch to IgE production (isotype switching)

A

IL-4

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7
Q

“B cell growth factor 2”,
eosinophil generation & activation
B cell & T cell growth & differentiation

A

IL-5

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8
Q

Initiation of the acute phase response
activation of B cell to plasma cells

A

IL-6

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9
Q

Stimulates proliferation of lymphoid progenitors

A

IL-7

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10
Q

Potent stimulator of neutrophils in chemotaxis

A

IL-8

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11
Q

Activates “respiratory burst” & release of specific azurophilic granule contents

A

IL-8

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12
Q

PROLIFERATION OF T CELLS, THYMOCYTES, MAST CELLS

A

IL-9

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13
Q

Inhibition of antigen presentation
inhibition of interferon gamma
suppression of Th2 cells

A

IL-10

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14
Q

Inhibition of B & t cell proliferation
induction of IgA
Inhibition of macrophages

A

TGF-B

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15
Q

Proinflammatory cytokines

A

IL-1, 6, 8, 15, 18, TNF-a

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16
Q

Anti-inflammatory cytokines

A

IL-10, 13, 35, TGF-b

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17
Q

Where is the site of B cell maturation?

A

Bone Marrow

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18
Q

Where is the site of T cell maturation?

A

Thymus

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19
Q

Where were the B & T cell produced?

A

Bone Marrow

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20
Q

Progenitor cells from BM migrate to the thymus and differentiate under the influence of ______?

A

Thymosin

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21
Q

What are the Secondary Lymphoid organs?

A

CLMS

CALT
Lymph node
MALT
Spleen

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22
Q

This traps antigen entering from subcutaneous

A

Lymph nodes

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23
Q

This traps Ag entering from blood

A

Spleen

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24
Q

Cells that is Ab mediated, primarily against bacterial infection

A

B cells

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25
Q

Cells that are cell-mediated, against viral, fungal tumor, and graft rejection

A

T cells

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26
Q

Location of Bcells in the Lymph nodes

A

Cortex

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27
Q

Location of B cells in the Spleen

A

Follicular area

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28
Q

Where is the location of T cells in the lymph nodes?

A

Paracortex

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29
Q

Where is the location of the t cells in the spleen?

A

PALS (Perinuclear Assoc. Lymphoid Sheath)

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30
Q

What are the CD MArkers of B cells?

A

CD 19
CD 20
CD 21
CD 25
CD 40
MHC 1 &2

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31
Q

CD 19 marker in B cells is what?

A

a pan marker

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32
Q

CD 20 in b cells is what?

A

Ion channel

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33
Q

CD 21 in b cells is associated with what?

A

EBV, C3D

34
Q

CD 25 in b cells is present in where?

A

activated b cell

35
Q

CD 40 in b cells is responsible for what process?

A

isotype switching & memory cell formation

36
Q

B CELLS percentage life span in the BM and PB

A

BM: 90%
PB: 10-15%

months to years

37
Q

What are the B CELL mitogens

A

LPS, SPA, Pokeweed mitogen

38
Q

What are the T cell mitogens?

A

PHA, Concanavalin A, pokeweed mitogen

39
Q

What are the t cell cd markers?

A

CD 2, 3, 4, 8

40
Q

T cells are present in spleen in what area?

A

PALS

40
Q

T cells are present in lymph nodes in what area?

A

Paracortex

41
Q

CD2 T cell CD marker is for what?

A

Classical marker for T cell (rosette formation)

42
Q

CD 3 t cell CD marker is for?

A

TCR complex

43
Q

CD4 T cell CD marker is found in what type of MHC complex?

A

MHC II

44
Q

T cell identification uses sheep rbcs forming what formation?

A

Rosette formation

45
Q

CD8 T cell CD marker is found in MHC what type?

A

MHC I

46
Q

T cells precentage in BM and PB?

A

BM: 10%
PB: 80%
others: 5-10% (NK cells)

47
Q

What is the GOLD STANDARD for the identifiucation of B and T cells?

A

FLOW CYTOMETRY

48
Q

What test uses sheep rbcs that binds to the CD2 marker forming Rosette formation?

A

Rosette test

49
Q

Rosette test identifies what type of cell?

A

T cells

50
Q

What test is used for lymphocyte separation?

A

Ficoll hypaque

51
Q

What is the SG in Ficoll Hypaque test?

A

1.077 - 1.114

52
Q

What sample is used for the Lymphocyte separation test?

A

Heparinized/ACD or defibrinated blood

53
Q

What is the normal CD4:CD8 ratio?

A

2:1

54
Q

What is the CD4:CD8 ratio during HIV?

A

1:2

55
Q

What the is the normal CD4 conc.?

A

500 - 1,200 /uL

56
Q

What is the CD4 conc during AIDS?

A

<200 /uL

57
Q

What is the CD marker for Th cells?

A

CD4

58
Q

What is the CD marker for Tc cells?

A

CD8

59
Q

What is the CD marker for Ts cells?

A

CD8

60
Q

What is the CD marker for Tm cells?

A

CD4. CD8

61
Q

What is the CD marker for Treg cells?

A

CD3, CD4, CD25

62
Q

These T cells limit the immune response

A

Treg, Ts

63
Q

A T cell that do surveillance and responsible for the anamnestiuc response

A

Tm (memory T cell)

64
Q

A t cell that secretes IL2, an d activates B cells into plasma cells

A

T helper cells (50-60%)

65
Q

A t cell that destroy infected cells, releases perforins and granzymes and secrete IFN-y

A

Cytotoxic t cells (20-25%)

66
Q

B cell maturation:
Pro B cell - presence of ?

A

CD19, CD45R

67
Q

B cell maturation:
Pre B cell-

A

IgM heavy chain + Light chain

68
Q

Heavy chain rearrangement at chromosome 14 is done in what stage of B cell maturation?

A

Pro B cell

69
Q

Light chain rearrangement at kappa and lambda was done in what stage of B cell maturation?

A

Pre B cell

70
Q

Naive/Immature B cells has what CD markers?

A

CD 19, 20, 21, 35

71
Q

The presence of surface IgM is on what stage of B cell maturation?

A

Immature B cell

72
Q

Mature B cell has what Immunoglobulins?

A

sIgM, sIgD

73
Q

Activated B cells has what CD marker?

A

CD25

74
Q

What stage of b cell maturation produces antibodies?

A

Plasma cells

75
Q

(T cell maturation)
Double negative T lymphocyte:

A

(-) CD4, CD8
(+) CD2

76
Q

(T cell maturation)
Double positive T lymphocyte:

A

(+) CD4, CD8

77
Q

Stage in t cell maturation where only the T cells with both markers survive

A

Positive Selection

78
Q

What stage in t cell maturation where the cells with strong reaction to self markers are deleted?

A

Negative selection

79
Q

(T cell maturation)
Clonal expansion of what?

A

Double Positive T cells

80
Q

What is the last stage of T cell maturation?

A

Single positive T Lymphocyte

81
Q
A

Immunoserology (21 decks)

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