Antigens

Question 1

What is a substance that provoke an immune response

Answer 1

Immunogen

Question 2

What do you call an incomplete antigen, non-immunogenic?

Answer 2

Hapten

Question 3

What is the carrier molecule and is immunogenic antigen called?

Answer 3

Schlepper molecule

Question 4

What is the ANTIGENIC DETERMINANT/ ANTIGEN BINDING SITE?

Answer 4

EPITOPE

Question 5

All immunogens are antigens, but not all antigens are immunogens. T/F?

Answer 5

TRUE

Question 6

What size of the antigen that is considered a STRONG IMMUNOGEN?

Answer 6

> /= 6 kD

Question 7

How many kilodaltons is need for an antigen to be immunogenic?

Answer 7

1 kD (10,000 daltons)

Question 8

What are the best immunogens?

Answer 8

Proteins

Question 9

Are glycolipids/glycoproteins, immunogens? Y/N

Answer 9

YES

Question 10

Nucleic acids and lipids are immunogenic. T/F

Answer 10

FALSE

Question 11

The DOSE above or below the optimal level will elicit an immune response. T/F

Answer 11

FALSE

Question 12

Subcutaneous & Intramuscular route is the BEST/WORST way of administration

Answer 12

BEST

Question 13

This enhances phagocytosis by increasing the the size and prevents rapid escape from the tissue

Answer 13

Alum precipitate

Question 14

this is derived from shark’s oil, used for HIC vaccines

Answer 14

Squalene

Question 15

This is a water in oil emulsion of killed M. tuberculosis and B. pertussis

Answer 15

Freund’s complete adjuvant

Question 16

ANTIGEN FROM THE HOST

Answer 16

AUTOANTIGEN

Question 17

AG FROM OTHER INDIVIDUAL WITH SAME GENOME

Answer 17

SYNGENEIC ANTIGEN (TWINS)

Question 18

ANTIGEN FROM OTHER INDIVIDUALS, SAME SPECIES

Answer 18

ALLOANTIGEN / HOMOLOHOUS / ALLOGENEIC / ISOANTIGEN

Question 19

ANTIGEN FROM OTHER SPECIES

Answer 19

HETEROANTIGEN / HETEROLOGOUS / HETEROGENEIC / XENOGENEIC

Question 20

AG THAT EXISTS IN UNRELATED PLANTS & ANIMALS BUT EITHER IDENTICAL OR CLOSELY RELATED, MAY CAUSE CROSS-RX

Answer 20

HETEROPHILE ANTIGENS

Question 21

An autologous antigen that does not come in contact with antibody producing cells

Answer 21

Sequestered antigen

Question 22

Antigen anturally present in the tissue

Answer 22

Tissue type antigen

Question 23

Antigen unique to a specific organ (PSA)

Answer 23

Tissue Specific antigen

Question 24

What do you call the transfer of tissue within the same individual?

Answer 24

Autograft

Question 25

What do you call the transfer of tissue to a genetically identical individual?

Answer 25

Isograft/Syngraft

Question 26

What do you call the transfer of tissue to a non-identical member of the same species?

Answer 26

Allograft

Question 27

What do you call the transfer of tissue to a member of different species?

Answer 27

Heterograft/Xenograft

Question 28

A graft rejection reaction that is humoral mediated

Answer 28

Hyper acute

Question 29

What are the 4 types of Graft rejection?

Answer 29

HYPERACUTE
ACCELERATED
ACUTE
CHRONIC

Question 30

How many hours does an Hyperacute graft rejection appear?

Answer 30

mins-hours

Question 31

The time it takes for the Accelerated Graft rejection to appear?

Answer 31

2-5 days

Question 32

The time it takes for the Acute Graft rejection to appear?

Answer 32

7-21 days

Question 33

The time it takes for the Chronic Graft rejection to appear?

Answer 33

> 3 months

Question 34

What type of graft rejection is caused by the pre-formed cytotoxic antibodies to donor antigens?

Answer 34

Hyperacute Graft Rejection

Question 35

What type of graft rejection is caused by the previous sensitization to antigens

Answer 35

Accelerated Graft Rejection

Question 36

What type of graft rejection is caused by the allogeneic reaction to donor antigens, mostly made by T cells

Answer 36

Acute Graft Rejection

Question 37

What type of graft rejection is caused by the disturbance of host vs graft tolerance, showing artherosclerosis, fibrosis, narrowing of lumen, and scarring

Answer 37

Chronic Graft Rejection