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Immunoserology > Antigen Presentation > Flashcards

Antigen Presentation Flashcards

1
Q

The MHC Class I presentation is also referred as

A

Endogenous/Cytosolic Pathway

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2
Q

The MHC Class II presentation is also referred as

A

Exogenous/Endocytic Pathway

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3
Q

Class I MHC is present in what cells?

A

All nucleated cells, plt, rbc,

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4
Q

Class I MHC has what chain?

A

Alpha chain, B2 microglobulin

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5
Q

Class II MHC has what chain?

A

Beta chain

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6
Q

Class II MHC is present on what type of cells?

A

APC, mononuclear cells

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7
Q

What is the other term of MHC found in humans?

A

HUman Leukocyte Antigen

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8
Q

HLA is present or produced in what chromosome?

A

Chromosome 6, short arm”p”

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9
Q

MHC Class I has what type of HLA?

A

HLA A,B,C

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10
Q

MHC Class I pairs with type of CD marker?

A

CD8 T cells (cytotoxic)

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11
Q

MHC Class II pairs with type of CD marker?

A

CD4 T cells

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12
Q

CD8 T cells are activated by what cytokine?

A

IL-2

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13
Q

What MHC class is used during viral replication, tumor, and graft rejection?

A

MHC I

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14
Q

What HLA is present in MHC Class II?

A

HLA D, DP, DQ, DR

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15
Q

Th cells become Th1 with the help of what cytokine?

A

IL-12

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16
Q

Th1 producces what cytokine?

A

IFN-y

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17
Q

Th1 produces IFN-y and helps in antibody secretion through?

A

Opsonization

18
Q

Th2 is activated by what interleukin?

A

IL-4

19
Q

Th2 produces what cytokines?

A

IL4 - IgE,. IgG4, isotope switching
IL5 - eosinophil

20
Q

Th2 is for mast cell degranulation and?

A

helminths destruction

21
Q

What MHC class directed to proteins, complement, and cytokines?

A

Class 3

22
Q

Class III MHC include what kinds of proteins/cytokines?

A

C2, C4, Factor B, TNF

23
Q

HLA B8 is associated with what disease/s?

A

Myasthenia Gravis, Addison’s disease, Grave’s disease

“8te my energy, adrenals, and thyroid”

24
Q

HLA B27 is associated with what disease/s?

A

“PAIR”
P- Psoriatic Arthritis
A - ANKYLOSING SPONDILITIS
I - Infectious Bowel Disease (Crohn’s, Ulcerative colitis, etc.)
R - Reactive Arthritis (Writer Syndrome)

25
Q

HLA DQ2 is associated with what disease/s?

A

Celiac Disease, DM type 1

26
Q

HLA DQ8 is associated with what disease/s?

A

DM type 1, Celiac Disease

27
Q

HLA DR3 is associated with what disease/s?

A

SLE, DM type 1, Grave’s dse

28
Q

HLA DR4 is associated with what disease/s?

A

RA, DM type 1

29
Q

An in vitro test that mimics the in vivo condition of transplantation

A

Mixed Lymphocyte Reaction

30
Q

In Mixed Lymphocyte Reaction, lymphocyttes are inactivated by?

A

Mytomycin C, Irradiation

31
Q

The amount of proliferation in Mixed Lymphocyte Reaction test is measured with the help of?

A

3H-labeled thymine
(tritium)

*measured using liquid scintillation counter

32
Q

Mixed Lymphocyte Reaction is best for what kind of tests?

A

BM graft, living related donors, HLA-B-D

33
Q

A kind of Tissue Matching test where PCR, and enzymes are used to cleave DNA for patterns and then assessed through comparison of fragments

A

RFLP (Restriction Fragment length Polymorphism)

34
Q

What dye is used in the Complement Mediated Microlymphocytotoxicity test, aka, CDC (Complement-dependent Cytotoxicity)?

A

Eosin Red, Trypan Blue

35
Q

What type of sample is used in the Complement Mediated Microlymphocytotoxicity test, aka, CDC (Complement-dependent Cytotoxicity)?

A

ACD or heparinized blood (1-2 mL)

36
Q

What microscope is used in reading the plates in the Complement Mediated Microlymphocytotoxicity test, aka, CDC (Complement-dependent Cytotoxicity)?

A

Inverted Phase COntrast Microscope

37
Q

Characteristics of uninjured cells in the Complement Mediated Microlymphocytotoxicity test, aka, CDC (Complement-dependent Cytotoxicity)?

A

small, bright, refractile

38
Q

Characteristics of injured cells in the Complement Mediated Microlymphocytotoxicity test, aka, CDC (Complement-dependent Cytotoxicity)?

A

flattened, large, dark, non-refractile
(+) HLA Ag

39
Q

HLA-DR typing requires the ID of what cell?

A

Bcell

40
Q

In HLA-DR typing, B cell is separated from the T cell using what substance?

A

Nylon wool

41
Q
A

Immunoserology (20 decks)

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