Hyperparathyroid Flashcards
1
Q
Clinical Features
A
Bone pain, fragility fractures, ↓BMD
Nephrolithiasis, Nephrocalcinosis, polyuria, renal insufficiency
Nausea, Vomiting, PUD, constipation, pancreatitis
Lethargy, decreased cognition, depressed mood, psychosis, coma
Gout, pseudo gout
LV Hypertrophy, ↓QT interval
2
Q
DDx
A
Vit D Deficiency Chronic Renal Insufficiency TSH Malignancy Adrenal Insufficiency
3
Q
Risk Factors
A
Age > 50 F > M Meds: Thiazide, Lithium Radiation to neck, radioactive iodine Genetic: MEN Type 1 + Type 2A, Familial Hypocalciuric Hypercalcemia, Familial Hyperparathyroidism – jaw tumor syndrome, Neonate severe hyperparathyroidism, Familial isolated hyperparathyroidism
4
Q
Investigations
A
PTH
Ca
Albumin
5
Q
Management of Primary Hyperparathyroidism
A
Volume Repletion
Loop Diuretics once euvolemic
Pamidronate or Zolindronate
Parathyroidectomy
