Hydroxocobalamin

Question 1

Brand name of Hydroxocobalamin

Answer 1

Cyanokit

Question 2

Drug class of Cyanokit

Answer 2

Antidote

Question 3

Indications of Cyanokit

Answer 3

Treatment of known or suspected cyanide poisoning

Question 4

Cyanokit’s mechanism of action

Answer 4

Binds with cyanide to from nontoxic cyanocobalamin (Vitamin B12), preventing its toxic effects; excreted renally.

Question 5

Contraindications for Cyanokit

Answer 5

None in the emergency setting

Question 6

Adverse effects of Cyanokit

Answer 6

Hypertension, allergic reactions, GI Bleeding, nausea, vomiting, dyspepsia, dyspnea, dizziness, headache, injection site reaction.

Question 7

Precautions of Cyanokit

Answer 7

Not compatible in the same IV line with many other medications

Question 8

Dose and admin of Cyanokit in an adult

Answer 8

5 grams IV infusion over 15 minutes at a rate of 15 mL/min. May repeat x1 at the same dose to a maximum of 10 grams

Question 9

Dose and admin of Cyanokit in a Pediatric Pt

Answer 9

70 mg/kg IV. May be repeated one time at the same dose.