Amyl Nitrate

Question 1

Generic and brand name of Amyl Nitrate

Answer 1

Amyl Nitrate (part of old cyanide antidote kit)

Question 2

Drug class of Amyl Nitrate

Answer 2

Antidote, cyanide poisoning adjunct

Question 3

Indications for Amyl Nitrate

Answer 3

Cyanide poisoning

Question 4

Amyl Nitrate’s mechanism of action

Answer 4

Convert hemoglobin to methemoglobin, which reacts with cyanide and chemically binds with it, preventing any toxic effects.

Question 5

Contraindication

Answer 5

None in the emergency setting

Question 6

Adverse effects of Amyl Nitrate

Answer 6

Headache, dizziness, weakness, increased ICP,
Shortness of breath, orthostatic hypotension,
Tachycardia, syncope, cyanosis

Question 7

Precaution in using Amyl Nitrate

Answer 7

Increased hypotensive effects if pt. is on
Antihypertensive meds, phenothiazine’s,
ETOH, or beta blockers

Question 8

Dose and administration of Amyl Nitrate

Answer 8

1 to 2 ampules crushed & inhaled for 30
Seconds each minute. After sodium nitrite
Admin, 30 seconds each 5 minutes
Pedi = 1 ampule, same rate