Clopidogrel

Question 1

Brand name of Clopidogrel

Answer 1

Plavix

Question 2

Drug class of Plavix

Answer 2

Anti-platelet

Question 3

Plavix’s mechanism of action

Answer 3

Inhibits platelet aggregation by blocking activation of the glycoprotein IIb/IIIa complex. This reduces platelet aggregation.

Question 4

Indications for Plavix

Answer 4

ST elevation Mi, moderate-to high-risk non-ST elevation MI, Acute Coronary Syndrome, substitute for Aspirin. Post MI and Post stent placement.

Question 5

Contraindications of Plavix

Answer 5

Active GI bleeding, Hypersensitivity,

Intracranial hemorrhage

Question 6

Adverse Effects of Plavix

Answer 6

GI hemorrhage, cerebral hemorrhage, angioedema, flulike symptoms, thrombotic thrombocytopenic purpura (TTP)

Question 7

Precautions for Plavix

Answer 7

Nexium and Prilosec (proton pump inhibitors)

May inhibit the effects of Plavix

Question 8

Dose and admin for Plavix

Answer 8

300 to 600 mg loading dose p.o.
Then 75 mg daily p.o.
Pediatric: Not recommended