hormonal regulation of growth

Question 1

name the hormones that regulate growth

Answer 1

thyroid hormone
insulin
testosterone
oestrogens
growth hormone
IGF-1
calcitonin, PTH , vit D

Question 2

explain the secretion of growth hormone

Answer 2

growth hormone releasing hormone from the hypothalamus stimulates the release of growth hormone from somatotrophs in the anterior pituitary

Question 3

growth hormone is part of which axis

Answer 3

hypothalamic-pituitary-liver axis

Question 4

explain the synthesis of growth hormone

Answer 4

preprohormone in rough ER of somatotrophs of ant pit
pro-hormone is located in Golgi and then final hormone located in secretory granules

Question 5

what inhibits GH release

Answer 5

somatostatin

Question 6

which hormone regulate GH gene expression

Answer 6

thyroid hormone

Question 7

a defficiency in thyroid hormone =

Answer 7

GH deficiency

Question 8

what is the role of IGF-1 in GH secretion

Answer 8

GH stimulates IGF-1 secretion in liver
IGF-1 then negatively feedbacks to GHRH-secreting arcuate nuclei and stimulates somatostatin secreting paraventricular neurons

Question 9

when is GH secretion at its highest (GH secretion is pulsatile)

Answer 9

during sleep