Homeostasis Flashcards

1
Q

Importance of maintaining constancy of the internal environment

A

To ensure fundamental life processes are able to take place optimally

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2
Q

Process of negative feedback

A
  1. Magnitude of change is sensed by receptor
  2. This information is fed back to integrating centre (hypothalamus)
  3. Compared to reference level
  4. Any difference between reference level generates another signal
  5. This signal is fed to an effector mechanism which produces a response to correct original change
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3
Q

`Explain feed-forward control

A

Changes made in the anticipation of change

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4
Q

Homeotherms

A

Maintain a constant core temperature over a wide range of external temperatures

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5
Q

Describe the principles behind negative feedback control systems

A

Oscillation around the set point

Cannot prevent it from happening but restores variable after displacement

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6
Q

Examples of feed-forward control

A

Changes in heart rate and respiratory rate before exercise

Skin detects external temperature change before change in core temperature occur

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7
Q

Positive Feedback Mechanism

A

In the output exaggerates or enhances the original stimulus
Homeostatic control of blood glucose
Depolarisation

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8
Q

Daily water balance in man

A

60% of body weight is water
1/3 ECF
2/3 ICF
40 L of fluid

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9
Q

Different body fluid compartments

A

ICF
(ISF
Plasma)- ECF

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10
Q

Insensible loss

A

moisture lost from the body through sweat and breath

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11
Q

ICF

A

Fluid within the cells

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12
Q

ISF

A

Fluid that bathes the outside of the cells

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13
Q

Plasma

A

Fluid component of blood

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14
Q

Plasma exchanges components with____

A

ISF

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15
Q

All 3 compartments are freely permeable to______ but not_____

A

Water, gases and glucose not ions

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16
Q

Importance of barriers

A

To maintain composition of the ECF for individual cells survival

17
Q

Dilution Principle

A

Volume of distribution = Amount of tracer/concentration of tracer
V = M/C

18
Q

Compartments that can be measured directly using the dilution principle

A

Plasma Volume- plasma proteins cannot cross capillary walls. Radioactive labels attached to plasma proteins
ECF Volume: Inulin and sucrose are too large to cross the cell membrane but can freely cross the capillary walls
Total body water:No barrier to water (heavy water)

19
Q

How would you work out the ECF volume/Volume of Distribution in this scenario:
150mg injected into 70KG
10mg were excreted or metabolised
Sucrose blood sample after distribution = 0.01mg/ml

A

Amount injected -(any metabolised/concentration of sample fluid)=
(150mg -10mg )/0.01 = 14,000ml/ 14 L

20
Q

ISF=

ICF=

A
ISF= ECF-PV
ICF= TBW-ECF