Essential Pharmacology Flashcards
1
Q
Plasma Membrane Receptors
A
Ionotropic
Enzymes
Protein that alter enzyme activity
G proteins
2
Q
G-protein coupled receptors
A
Hormone binds to G protein
G protein alpha subunit binds GTP and dissociates Couples to adenyl cyclase- breaks down ATP» CAMP- activates protein kinase A
Couples to phospholipase C- IP3 and DAG-> PKC and Ca2+
3
Q
Sources of Ca2+
A
Internal stores IP3
Outside cell (voltage gated or ligand gated)
Sarcoplasmic reticulum
4
Q
Effects of Ca2+
A
Directly affects target protein PKC
Binds to calmodulin- smooth muscle
Binds to troponin- skeletal muscle
5
Q
Drug affinity
A
does it bind to receptors
6
Q
Drug efficacy
A
does it activate receptor
7
Q
Full agonist
A
high efficacy and affinity
8
Q
Partial agonist
A
High affinity, partial efficacy
9
Q
Antagonost
A
High affinity, no efficacy
