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Pharmacology > Histamine and Serotonin - 5 > Flashcards

Histamine and Serotonin - 5 Flashcards

0
Q

Chemical and mechanical release

A

displace histamine from heparin-protein complex within cell

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1
Q

Immunological release

A

mast cell and basophil degranulation

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2
Q

First generation antihistamines

A

cause sedation, more likely to block autonomic receptors

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3
Q

Second generation antihistamines

A

less sedating, poor distribution into CNS

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4
Q

Mepyramine

A

(1st gen antihistamine) insect bite ointment

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5
Q

Diphenhydramine

A

1st gen antihistamine

-sedative in adults, causes hyperactivity in children

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6
Q

Doxylamine

A

1st gen antihistamine

decongestant - no rebound swelling

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7
Q

Triprolidine

A

1st gen antihistamine

decongestant - no rebound swelling

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8
Q

Brompheniramine

A

1st gen antihistamine

hay fever aid

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9
Q

Hydroxyzine

A

1st gen antihistamine

anxiolytic - due to antiserotonergic activity

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10
Q

Promethazine

A

1st gen antihistamine

Sedative, anti-emetic (due to CNS effects)

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11
Q

Cyproheptadine

A

1st gen antihistamine

Orexigenic (appetite stimulant) - antiserotonergic activity

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12
Q

Cetirizine

A

2nd gen antihistamine

Allergies, uticaria

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13
Q

Levocetirizine

A

2nd gen antihistamine

hay fever allergies

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14
Q

Loratadine

A

2nd gen antihistamine

hay fever, skin allergies

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15
Q

Desloratadine

A

2nd gen antihistamine

allergies

16
Q

Terfenadine

A

2nd gen antihistamine
allergies
WITHDRAWN due to cardiotoxicity

17
Q

Fexofenadine

A

2nd gen antihistamine

hay fever, uticaria

18
Q

Cimetidine

A

H2 antagonist, antiandrogenic effects

used to treat peptic ulcers

19
Q

Ranitidine, fimotidine, nizatidine

A

H2 antagonist - used to treat peptic ulcers

20
Q

Cromoglicic acid

A

Mast cell stabilizer - blocks calcium channels needed for degranulation
-asthma, allergic rhinitis, allergic conjunctivitis

21
Q

Nedocromil

A

Mast cell stabilizer - blocks calcium channels needed for degranulation
-asthma

22
Q

5-Hydroxytryptamine

A

Serotonin

-neurotransmitter in CNS and enteric nervous system

23
Q

5-HT1 receptors

A

found in CNS and some blood vessels

-neural inhibition and vasoconstriction

24
Q

5-HT1D Agonists

A 
1 trip erg in the bus
-cerebral vasoconstricion
triptans
ergotamine
busiprone
25
Q

5-HT2A receptors

A

CNS, PNS, smooth muscle, platelets

-neuronal excitation, smooth muscle contraction, platelet aggregation, vasoconstriction.

26
Q

5-HT3 receptors

A

anti-emetic receptors

-ligand fated channel

27
Q

Serotonin Syndrome

A
  • severe muscle rigidity, cardiovascular instability, seizures
  • treated with anticonvulsants, muscle relaxants and cyproheptadine

Pharmacology (17 decks)

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