Gout - 3 Flashcards
0
Q
Corticosteroid mechanism
A
induces lipocortin, preventing natural inflammatory cascade
1
Q
Drugs that cause gout
A
CANT LEAP
- cyclosporine or cancer drugs
- aspirin
- niacin
- thiazide (only high doses)
- lasix (furosemide)
- ehtambutol
- alcohol
- pyrizinamide
2
Q
Colchicine dosage:
A
1mg + 0.5mg every 6hrs, max 2.5mg every 24hrs
3
Q
Colchicine
A
NSAID
narrow TI
stop immediately with
GIT side effects
4
Q
Xanthine Oxidase Inhibitors
A
Allopurinol
Febuxostat
5
Q
Recombinant Urate Oxidase Enzyme
A
Rasburicase
6
Q
Uricosuric agents
A
Probenecid - increases excretion rate of urate and prevents reabsorption
7
Q
Anti-Inflammatories
A
NSAIDS, corticosteroids, colchicine, IL-1 antagonists
