Drugs Affecting Calcium Homeostasis -4

Question 0

Serotonin inhibitors

Answer 0

Calcium antagonistic effect on smooth muscle, particularly vascular endothelium.

Question 1

Proton pump inhibitors (PPI’s)

Answer 1

reduce gastric acid production resulting in reduced calcium absorption.

Question 2

Calcitonin and Bisphosphonates

Answer 2

Cause chelation and end organ inhibition of osteoclast activity

Question 3

Phenobarbital

Answer 3

Enhances vit. D catabolism and decreases calcium resorption in gut.
-anti-epileptic

Question 4

Phenytoin

Answer 4

Enhances vit. D catabolism and decreases calcium resorption in gut.
-anti epileptic

Question 5

Foscarnet

Answer 5

complexes with calcium

-used for herpes

Question 6

Fluoride

Answer 6

Chelates calcium avidly and causes profound hypocalcaemia

Question 7

Hydrofluoric acid

Answer 7

Chelates calcium avidly and causes profound hypocalcaemia

Question 8

Estrogen

Answer 8

Inhibits bone resorption

Question 9

Cimetidine

Answer 9

decreases gastric pH, slowing fat beakdown, which is necessary to complex calcium for gut absorption.
-H2 receptor blocker - peptic ulcer treatment

Question 10

Aluminium

Answer 10

supresses PTH

-used as antacid salts

Question 11

Alcohol

Answer 11

Suppresses PTH

Question 12

Treatment of Hypercalcaemia

Answer 12

Bisphosphonates, calcitonin, corticosteroids (Hypercalcaemia caused by Vit. D toxicity)

Question 13

Pamidronate

Answer 13

Bisphosphonate

Question 14

Alendronate

Answer 14

Bisphosphonate

Question 15

Zoledronate

Answer 15

Bisphosphonate

Question 16

Causes of non-PTH mediated Hypercalcaemia

Answer 16

Thiazides (diuretics)
Calcium carbonate (antacid)
Hypervitaminosis D
Hypervitaminosis A (activates bone resorption)
Lithium (bipolar - raises set point for PTH suppression)