Autonomic Nervous System - 5 Flashcards
alpha-1
- causes smooth muscle contraction
- phenylephedrine stimulates
- prazosin inhibits
alpha-2
- auto inhibitory
- clonidine stimulates
- mianserin inhibits
Beta-1
- increases heart rate and contraction force
- stimulated by dobutamine
- inhibited by propranolol and atenolol
Beta-2
- smooth muscle relaxation
- stimulated by salbutamol and hexoprenaline
- inhibited by propranolol
Beta-3
-stimulation causes fat lipolysis
Nor-adrenaline re-uptake inhibitors
Cocaine
TCA’s
COMT
inhibits breakdown of noradrenaline
Nicotinic receptors
- stimulated by nicotine and lobeline
- inhibited by hexamethonium and trimetaphan
Muscarinic receptors
- stimulated by pilocarpine
- inhibited by atropine
Bethanecol
M3 - causes bladder constriction, increased peristalsis and bronchoconstriction
Tropicamide
inhibits pupil constriction and ciliary muscle contraction (inhibition causes lens to flatten)
Cyclopentolate
inhibits pupil constriction and ciliary muscle contraction (inhibition causes lens to flatten)
Atropine
Anti-muscarinic drug: causes dry mouth, blurred vision, urinary retention, constipation
(anticholinergic, parasympatholytic)