Glucocorticosteroids - 4

Question 0

Cortisone

Answer 0

cheap; converted to hydrocortisone (active)

-serious mineralocorticoid effects, seldom used

Question 1

Cortisol

Answer 1

use in emergency and replacement

Question 2

Corticosterone

Answer 2

not used

Question 3

Prednisolone

Answer 3

• systemic anti inflammatory; immune suppressant

- also for allergic skin reactions and ophthalmic diseases

Question 4

Prednisone

Answer 4

inactive form of prednisolone

Question 5

Methylprednisolone

Answer 5

• anti inflammatory and immune supressant

- less water retention

Question 6

Triamcinolone

Answer 6

-more toxic; anti inflammatory and immune suppressant

Question 7

Dexamethasone

Answer 7

most potent anti inflammatory and immune suppressive

• used for cerebral oedema and ACTH suppression (no water retention)
• also for severe muscle and joint pain

Question 8

Betamethasone

Answer 8

very potent anti inflammatory and immune suppressant

• used for cerebral oedema and ACTH suppression
• also used for severe muscle and joint pain

Question 9

Beclomethasone

Answer 9

Topical and inhalation

Question 10

Budenoside

Answer 10

Topical and inhalation

Question 11

Mechanism of action

Answer 11

• binds to corticosteroid binding protein in cytoplasm
• binds to receptor - transcription of new genes
• produces LIPOCORTIN polypeptide

Question 12

Cushing’s syndrome

Answer 12

moon face, striae, buffalo hump, thinning of skin, easy bruising, poor wound healing, susceptible to infection, ankle oedema

Question 13

Side effects

Answer 13

CNS, glaucoma, skin, muscle and bone atrophy, hyperglycaemia, sodium retention, potassium loss, bleeding stomach ulcers.