High Yield Flashcards
How does sympathetic firing effect currents in the SA and AV node?
It would increase ICaL, If and IK
What does sympathetic firing do to atrial and ventricle currents?
Increases ICaL and increases IK
No change in INa
What is the overall effect of sympathetic stimulation to the SA node?
More positive MDP, increase phase 4 depolarization, decrease action potential duration
What is the overall effect of sympathetic stimulation to the AV node?
Increase conduction velocity and increase P0 depolarization
What is the overall effect of sympathetic stimulation to the atrial and ventricular myocytes?
More positive phase 2 and duration of the AP will decrease
What is the effect on currents from parasympathetic stimulation to the SA and AV node?
Decrease : ICaL, If, IK
Increase: IKAch
What will be the overall effect of parasympathetic stimulation to the SA node?
Decrease HR, more neg MDP, slower phase 4, increased AP duration
In a person with chronic hypertension, how would their response differ for a normal person when going from supine to sitting?
The individual with chronic hypertension would experience a greater drop in arterial pressure due to baroreceptor desensitivity.
What is the Fick Equation?
CO = (O2 Consumption)/(O2 Artery - O2 Veins)
How does a beta 1 receptor alter current in the SA and AV node, as well as Atrial and ventricular myocytes?
SA + AV = Increased If and ICaL
Atrial and Vent Myo - Increased ICaL and Ik
What is the equation for net filtration?
(Pc - Pi) - (Oncotic pressure P - Oncotic pressure I)
Membrane potential formula?
V = (fgK x Ek) + (fgNa x ENa)
TPR formula?
TPR = (MAP - RAP)/CO
Ejection fraction formula?
Ejection fraction = SV/EDV
What is the biggest determinant of O2 consumption?
Increasing or decreasing inotropic state
How will hyper/hypokalemia effect MDP?
Hyper - More negative
Hypo - Less negative
How does the QRS complex change in hyper/hypokalemia?
It widens
What is the effect of resting depolarization of the membrane on Na Channels?
Decreases the number of available resting Na channels
What are some things that can lead to a flat T wave?
Hypokalemia, decreased Ik current, Beta antagonist or decreased sympathetic firing
What are some causes of wide splitting of S2?
Pulmonary stenosis or Right bundle branch block