3.1.4 Vasculitis Disorders

Question 1

What is Churg-Strauss Syndrome?

Answer 1

Systemic vasculitis associated with prominent eosinophilia that occurs in young persons with astham or allergy

Question 2

What is this?

Answer 2

Fibrinoid necrosis associated with polyarteritis nodosa

Question 3

What is this an image of?

Answer 3

Polyarteritis nodosa

Question 4

What is this an image of?

Answer 4

Microscopic Polyangiitis

Question 5

What are the pathological indications of giant cell arteritis?

Answer 5

Multinucleated giant cells

Cordlike, nodular vessel with narrow lumen

Fibrous media and thickened intima

Question 6

In giant cell arteritis what are each of the images?

Answer 6

The image on the left in showing granulmonas while the image on the right is showing mixed inflammation with necrosis

Question 7

Takayasu arteritis is also known as what?

Answer 7

The pulseless disease

Question 8

What is Wegner Granulomatosis?

Answer 8

Systemic necrotizing granulomatous vasculitis of unknown etiology.

Question 9

What are the pathological findings associated with thromboangiitis obliterans?

Answer 9

Thrombosis and infarcts. Gangrene.

Question 10

What are the pathological characteristic of polyarteritis nodosa?

Answer 10

Affecting small to medium vessels. Fibrinoid necrosis. Thrombosis and infarction of an organ

Question 11

How do you treat Takayasu arteritis?

Answer 11

Steroids and surgical reconstruction

Question 12

How would you treat Giant cell arteritis?

Answer 12

Steroids and anti-TNF

Question 13

What is this an image of?

Answer 13

Giant cell arteritis

Question 14

What would the gross and pathological finding be in a person with microscopic polyangiitis?

Answer 14

Localized cutaneous vasculitis - Gross

Patho - finrinoid necrosis, acute inflammation, and extravasation of RBCs

Question 15

What are the hallmark characteristic of giant cell ateritis?

Answer 15

Also known as Temporal, Granulomatous Ateritis. It is the most common form of vasculitis. Focal, chronic, granulomatous inflammation of the temporal artery. Multinucleated giant cells

Question 16

How would you treat Churg-Strauss Syndrome?

Answer 16

STEROIDS

Question 17

What are the clinical features of Takayasu arteritis?

Answer 17

Weak or non-existant pulse

high BP

Ocular disturbances

syncope and dizziness

Question 18

Is a biopsy diagnostic for giant cell arteritis?

Answer 18

It can be, but it is not in over 40% of cases

Question 19

What is polyarteritis nodosa?

Answer 19

Acute necrotizing vasculitis of medium-sized muscular arteries.

Associated with hepatitis B

Question 20

When looking at anti-proteinase-3 (PR3-ANCA and c-ANCA) what disease are you monitoring?

Answer 20

Wegeners granulomatosis

Question 21

Microscopic polyangiitis is also known as ?

Answer 21

Systemic hypersensitivity polyarteritis

Question 22

What is kawasaki disease?

Answer 22

Acute necrotizing vasculitis of infancy and early childhood, w fever, rash, oral lesion and lymphadenitis

Question 23

What is being shown in the image on the left and right?

Answer 23

Vasculitis (L) and Necrotizing granuloma (R)

Question 24

What is the clinical triad of affected organs for Wegener Granulomatosis?

Answer 24

Lungs, Kidney, and Upper Respiratory Tract

Question 25

What is microscopic polyangiitis?

Answer 25

A group of inflammatory vascular lesions affecting small vessels that are thought to represent a response to exogenous substances

Question 26

What disease are these two images assciated with?

Answer 26

Takayasu arteritis

Question 27

What is vasculitis?

Answer 27

Inflammation and necrosis of blood vessels (arteries, veins and capillaries)

Question 28

What is Takayasu arteritis?

Answer 28

Inflammatory disease of unknown etiology, affecting large arteries (aorta and branches)

Question 29

What can happen to patients with giant cell arteritis that goes untreated?

Answer 29

Blindness

Question 30

What looking at MPO-ANCA and p-ANCA (anti-myeloperoxidase), what diseases are you looking for?

Answer 30

Microscopic polyangiitis and Churg-Strauss

Question 31

Summarize all the vasculitis disorders in one image

Answer 31

CAN DO!

Question 32

How would you treat Kawasaki disease?

Answer 32

AKA mucocutaneous lymph node syndrome. **IVIG and asprin.**

Question 33

What are some clinical features of Wegener Granulomatosis?

Answer 33

Sinusitis, **Hematuria and proteinuria**

Question 34

What is this gross image associated with?

Answer 34

Wegener Granulomatosis

Question 35

What is this an image of?

Answer 35

Microscopic Polyangiitis

Question 36

What is this an image of?

Answer 36

Polyarteritis nodosa

Question 37

What is this an image of?

Answer 37

Giant cell arteritis

Question 38

What are the microscopic findings associated with microscopic polyangiitis?

Answer 38

Fibrinoid necrosis of blood vessel walls Intramural neutrophilic infiltrates RBC extravasation Endothelial cell swelling

Question 39

What disease is this gross image associated with?

Answer 39

Microscopic polyangiitis

Question 40

Who is mostly affected by thromboangiitis obliterans?

Answer 40

Smokers and young middle aged men

Question 41

What is this an image of?

Answer 41

Progression of thromboangiitis obliterans. Right is the worst.

Question 42

The left image is normal what is wrong in the right image?

Answer 42

Fragmentation of elastic lamina associated with giant cell arteritis

Question 43

What is this an image of?

Answer 43

Takayasu arteritis

Question 44

What is thromboangiitis obliterans?

Answer 44

Occlusive inflammatory disease of medium and small arteries in the distal arms and legs