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Cardiology > 3.1.4 Vasculitis Disorders > Flashcards

3.1.4 Vasculitis Disorders Flashcards

1
Q

What is Churg-Strauss Syndrome?

A

Systemic vasculitis associated with prominent eosinophilia that occurs in young persons with astham or allergy

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2
Q

What is this?

A

Fibrinoid necrosis associated with polyarteritis nodosa

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3
Q

What is this an image of?

A

Polyarteritis nodosa

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4
Q

What is this an image of?

A

Microscopic Polyangiitis

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5
Q

What are the pathological indications of giant cell arteritis?

A

Multinucleated giant cells

Cordlike, nodular vessel with narrow lumen

Fibrous media and thickened intima

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6
Q

In giant cell arteritis what are each of the images?

A

The image on the left in showing granulmonas while the image on the right is showing mixed inflammation with necrosis

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7
Q

Takayasu arteritis is also known as what?

A

The pulseless disease

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8
Q

What is Wegner Granulomatosis?

A

Systemic necrotizing granulomatous vasculitis of unknown etiology.

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9
Q

What are the pathological findings associated with thromboangiitis obliterans?

A

Thrombosis and infarcts. Gangrene.

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10
Q

What are the pathological characteristic of polyarteritis nodosa?

A

Affecting small to medium vessels. Fibrinoid necrosis. Thrombosis and infarction of an organ

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11
Q

How do you treat Takayasu arteritis?

A

Steroids and surgical reconstruction

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12
Q

How would you treat Giant cell arteritis?

A

Steroids and anti-TNF

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13
Q

What is this an image of?

A

Giant cell arteritis

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14
Q

What would the gross and pathological finding be in a person with microscopic polyangiitis?

A

Localized cutaneous vasculitis - Gross

Patho - finrinoid necrosis, acute inflammation, and extravasation of RBCs

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15
Q

What are the hallmark characteristic of giant cell ateritis?

A

Also known as Temporal, Granulomatous Ateritis. It is the most common form of vasculitis. Focal, chronic, granulomatous inflammation of the temporal artery. Multinucleated giant cells

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16
Q

How would you treat Churg-Strauss Syndrome?

A

STEROIDS

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17
Q

What are the clinical features of Takayasu arteritis?

A

Weak or non-existant pulse

high BP

Ocular disturbances

syncope and dizziness

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18
Q

Is a biopsy diagnostic for giant cell arteritis?

A

It can be, but it is not in over 40% of cases

19
Q

What is polyarteritis nodosa?

A

Acute necrotizing vasculitis of medium-sized muscular arteries.

Associated with hepatitis B

20
Q

When looking at anti-proteinase-3 (PR3-ANCA and c-ANCA) what disease are you monitoring?

A

Wegeners granulomatosis

21
Q

Microscopic polyangiitis is also known as ?

A

Systemic hypersensitivity polyarteritis

22
Q

What is kawasaki disease?

A

Acute necrotizing vasculitis of infancy and early childhood, w fever, rash, oral lesion and lymphadenitis

23
Q

What is being shown in the image on the left and right?

A

Vasculitis (L) and Necrotizing granuloma (R)

24
Q

What is the clinical triad of affected organs for Wegener Granulomatosis?

A

Lungs, Kidney, and Upper Respiratory Tract

25
Q

What is microscopic polyangiitis?

A

A group of inflammatory vascular lesions affecting small vessels that are thought to represent a response to exogenous substances

26
Q

What disease are these two images assciated with?

A

Takayasu arteritis

27
Q

What is vasculitis?

A

Inflammation and necrosis of blood vessels (arteries, veins and capillaries)

28
Q

What is Takayasu arteritis?

A

Inflammatory disease of unknown etiology, affecting large arteries (aorta and branches)

29
Q

What can happen to patients with giant cell arteritis that goes untreated?

A

Blindness

30
Q

What looking at MPO-ANCA and p-ANCA (anti-myeloperoxidase), what diseases are you looking for?

A

Microscopic polyangiitis and Churg-Strauss

31
Q

Summarize all the vasculitis disorders in one image

A

CAN DO!

32
Q

How would you treat Kawasaki disease?

A

AKA mucocutaneous lymph node syndrome. IVIG and asprin.

33
Q

What are some clinical features of Wegener Granulomatosis?

A

Sinusitis, Hematuria and proteinuria

34
Q

What is this gross image associated with?

A

Wegener Granulomatosis

35
Q

What is this an image of?

A

Microscopic Polyangiitis

36
Q

What is this an image of?

A

Polyarteritis nodosa

37
Q

What is this an image of?

A

Giant cell arteritis

38
Q

What are the microscopic findings associated with microscopic polyangiitis?

A

Fibrinoid necrosis of blood vessel walls

Intramural neutrophilic infiltrates

RBC extravasation

Endothelial cell swelling

39
Q

What disease is this gross image associated with?

A

Microscopic polyangiitis

40
Q

Who is mostly affected by thromboangiitis obliterans?

A

Smokers and young middle aged men

41
Q

What is this an image of?

A

Progression of thromboangiitis obliterans. Right is the worst.

42
Q

The left image is normal what is wrong in the right image?

A

Fragmentation of elastic lamina associated with giant cell arteritis

43
Q

What is this an image of?

A

Takayasu arteritis

44
Q

What is thromboangiitis obliterans?

A

Occlusive inflammatory disease of medium and small arteries in the distal arms and legs

Cardiology (46 decks)

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