3.1.4 Vasculitis Disorders Flashcards
What is Churg-Strauss Syndrome?
Systemic vasculitis associated with prominent eosinophilia that occurs in young persons with astham or allergy
What is this?
Fibrinoid necrosis associated with polyarteritis nodosa
What is this an image of?
Polyarteritis nodosa
What is this an image of?
Microscopic Polyangiitis
What are the pathological indications of giant cell arteritis?
Multinucleated giant cells
Cordlike, nodular vessel with narrow lumen
Fibrous media and thickened intima
In giant cell arteritis what are each of the images?
The image on the left in showing granulmonas while the image on the right is showing mixed inflammation with necrosis
Takayasu arteritis is also known as what?
The pulseless disease
What is Wegner Granulomatosis?
Systemic necrotizing granulomatous vasculitis of unknown etiology.
What are the pathological findings associated with thromboangiitis obliterans?
Thrombosis and infarcts. Gangrene.
What are the pathological characteristic of polyarteritis nodosa?
Affecting small to medium vessels. Fibrinoid necrosis. Thrombosis and infarction of an organ
How do you treat Takayasu arteritis?
Steroids and surgical reconstruction
How would you treat Giant cell arteritis?
Steroids and anti-TNF
What is this an image of?
Giant cell arteritis
What would the gross and pathological finding be in a person with microscopic polyangiitis?
Localized cutaneous vasculitis - Gross
Patho - finrinoid necrosis, acute inflammation, and extravasation of RBCs
What are the hallmark characteristic of giant cell ateritis?
Also known as Temporal, Granulomatous Ateritis. It is the most common form of vasculitis. Focal, chronic, granulomatous inflammation of the temporal artery. Multinucleated giant cells
How would you treat Churg-Strauss Syndrome?
STEROIDS
What are the clinical features of Takayasu arteritis?
Weak or non-existant pulse
high BP
Ocular disturbances
syncope and dizziness
Is a biopsy diagnostic for giant cell arteritis?
It can be, but it is not in over 40% of cases
What is polyarteritis nodosa?
Acute necrotizing vasculitis of medium-sized muscular arteries.
Associated with hepatitis B
When looking at anti-proteinase-3 (PR3-ANCA and c-ANCA) what disease are you monitoring?
Wegeners granulomatosis
Microscopic polyangiitis is also known as ?
Systemic hypersensitivity polyarteritis
What is kawasaki disease?
Acute necrotizing vasculitis of infancy and early childhood, w fever, rash, oral lesion and lymphadenitis
What is being shown in the image on the left and right?
Vasculitis (L) and Necrotizing granuloma (R)
What is the clinical triad of affected organs for Wegener Granulomatosis?
Lungs, Kidney, and Upper Respiratory Tract
What is microscopic polyangiitis?
A group of inflammatory vascular lesions affecting small vessels that are thought to represent a response to exogenous substances
What disease are these two images assciated with?
Takayasu arteritis
What is vasculitis?
Inflammation and necrosis of blood vessels (arteries, veins and capillaries)
What is Takayasu arteritis?
Inflammatory disease of unknown etiology, affecting large arteries (aorta and branches)
What can happen to patients with giant cell arteritis that goes untreated?
Blindness
What looking at MPO-ANCA and p-ANCA (anti-myeloperoxidase), what diseases are you looking for?
Microscopic polyangiitis and Churg-Strauss
Summarize all the vasculitis disorders in one image
CAN DO!
How would you treat Kawasaki disease?
AKA mucocutaneous lymph node syndrome. IVIG and asprin.
What are some clinical features of Wegener Granulomatosis?
Sinusitis, Hematuria and proteinuria
What is this gross image associated with?
Wegener Granulomatosis
What is this an image of?
Microscopic Polyangiitis
What is this an image of?
Polyarteritis nodosa
What is this an image of?
Giant cell arteritis
What are the microscopic findings associated with microscopic polyangiitis?
Fibrinoid necrosis of blood vessel walls
Intramural neutrophilic infiltrates
RBC extravasation
Endothelial cell swelling
What disease is this gross image associated with?
Microscopic polyangiitis
Who is mostly affected by thromboangiitis obliterans?
Smokers and young middle aged men
What is this an image of?
Progression of thromboangiitis obliterans. Right is the worst.
The left image is normal what is wrong in the right image?
Fragmentation of elastic lamina associated with giant cell arteritis
What is this an image of?
Takayasu arteritis
What is thromboangiitis obliterans?
Occlusive inflammatory disease of medium and small arteries in the distal arms and legs
